Maternal obesity, diabetes during pregnancy and epigenetic mechanisms that influence the developmental origins of cardiometabolic disease in the offspring

P Agarwal, TS Morriseau, SM Kereliuk… - Critical reviews in …, 2018 - Taylor & Francis
Since 1980, global obesity has doubled, and the incidence of cardiometabolic diseases
such as type 2 diabetes and heart disease is also increasing. While genetic susceptibility …

Impact of Maternal Diet on the Epigenome during In Utero Life and the Developmental Programming of Diseases in Childhood and Adulthood

HS Lee - Nutrients, 2015 - mdpi.com
Exposure to environmental factors in early life can influence developmental processes and
long-term health in humans. Early life nutrition and maternal diet are well-known examples …

[HTML][HTML] Neonatal insulin action impairs hypothalamic neurocircuit formation in response to maternal high-fat feeding

MC Vogt, L Paeger, S Hess, SM Steculorum… - Cell, 2014 - cell.com
Maternal metabolic homeostasis exerts long-term effects on the offspring's health outcomes.
Here, we demonstrate that maternal high-fat diet (HFD) feeding during lactation predisposes …

Maternal high-fat diet alters methylation and gene expression of dopamine and opioid-related genes

Z Vucetic, J Kimmel, K Totoki, E Hollenbeck… - …, 2010 - academic.oup.com
Maternal obesity during pregnancy increases the risk of obesity in the offspring. Obesity,
arising from an imbalance of energy intake and expenditure, can be driven by the ingestion …

Enduring consequences of maternal obesity for brain inflammation and behavior of offspring

SD Bilbo, V Tsang - The FASEB Journal, 2010 - Wiley Online Library
Obesity is well characterized as a systemic inflammatory condition, and is also associated
with cognitive disruption, suggesting a link between the two. We assessed whether …

Effects of maternal and paternal exercise on offspring metabolism

J Kusuyama, AB Alves-Wagner, NS Makarewicz… - Nature …, 2020 - nature.com
Maternal and paternal obesity and type 2 diabetes are recognized risk factors for the
development of metabolic dysfunction in offspring, even when the offspring follow a healthful …

A review of the impact of dietary intakes in human pregnancy on infant birthweight

JA Grieger, VL Clifton - Nutrients, 2014 - mdpi.com
Studies assessing maternal dietary intakes and the relationship with birthweight are
inconsistent, thus attempting to draw inferences on the role of maternal nutrition in …

Maternal nutritional history predicts obesity in adult offspring independent of postnatal diet

GJ Howie, DM Sloboda, T Kamal… - The Journal of …, 2009 - Wiley Online Library
Significant alterations in maternal nutrition may induce long‐term metabolic consequences
in offspring, in particular obesity and leptin and insulin resistance. Although maternal …

Effects of maternal surgical weight loss in mothers on intergenerational transmission of obesity

J Smith, K Cianflone, S Biron, FS Hould… - The Journal of …, 2009 - academic.oup.com
Background and Objectives: By studying cardiometabolic risk factors in children born after
maternal biliopancreatic diversion bariatric surgery (AMS) compared with those in children …

Developmental origins of adult disease

SC Langley-Evans, S McMullen - Medical principles and practice, 2010 - karger.com
Variation in the quality or quantity of nutrients consumed during pregnancy can exert
permanent and powerful effects upon the developing fetus. This programming of fetal …