The development and progression of cardiovascular disease (CVD) can mainly be attributed
to the narrowing of blood vessels caused by atherosclerosis and thrombosis, which induces …

Cardiovascular diseases are the leading cause of death around the world. Despite the
larger number of genes and loci identified, the precise mechanisms by which these genes …

Environmental factors are the largest contributors to cardiovascular disease. Here we show
that cardiac organoids that incorporate an oxygen-diffusion gradient and that are stimulated …

Sex differences in adipose tissue distribution and function are associated with sex
differences in cardiometabolic disease. While many studies have revealed sex differences in …

Genetics and environmental and lifestyle factors deeply affect cardiovascular diseases, with
atherosclerosis as the etiopathological factor (ACVD) and their early recognition can …

Despite declines in total cardiovascular mortality rates in the United States, heart failure (HF)
mortality rates as well as hospitalizations and readmissions have increased in the past …

Cardiometabolic diseases encompass a range of interrelated conditions that arise from
underlying metabolic perturbations precipitated by genetic, environmental, and lifestyle …

Aim: Multiomics delivers more biological insight than targeted investigations. We applied
multiomics to patients with heart failure (HF) and reduced ejection fraction (HFrEF), with …

Kidney fibrosis represents an urgent unmet clinical need due to the lack of effective
therapies and an inadequate understanding of the molecular pathogenesis. We have …

Conductances of ion channels and transporters controlling cardiac excitation may vary in a
population of subjects with different cardiac gene expression patterns. However, the amount …