Advanced pancreatic ductal adenocarcinoma (PDAC) and hepatocellular carcinoma (HCC)
are non-curable diseases with a particularly poor prognosis. Over the last decade, research …

The cross talk between tumor cells and the surrounding peritumoral stroma has been
extensively studied as a dynamic system involving the processes of hepatocarcinogenesis …

BACKGROUND & AIMS: Transforming growth factor (TGF)-β–activated kinase 1 (TAK1) is
activated in different cytokine signaling pathways. Deletion of Tak1 from hepatocytes results …

Hepatocellular carcinoma (HCC), is the sixth most frequent form of cancer and leads to the
fourth highest number of deaths each year. HCC results from a combination of …

Transforming growth factor-beta (TGF-β) is a multifunctional cytokine that performs a dual
role as a tumor suppressor and tumor promoter during cancer progression. Among different …

Hepatocellular carcinoma (HCC), the predominant form of primary liver cancer, is the sixth
most common cancer worldwide and the third leading cause of cancer-related death. The …

Hepatocellular carcinoma (HCC) is a major public health problem due to increased
incidence, late diagnosis and limited treatment options. TGF-β is known to provide cytostatic …

Abstract miR-211 up-regulation and transforming growth factor-β type II receptor (TGFβRII)
down-regulation are associated with poor prognosis of head and neck squamous cell …

Hepatocellular carcinoma (HCC) is often associated with an inflammatory setting. A plethora
of cytokines are secreted in this milieu, actively contributing to the progression of the …

Hepatocellular carcinoma (HCC) is one of the most common and rapidly fatal malignancies
worldwide with a multifactorial, multistep, complex process and poor prognosis. Its early …