Promyelocytic leukemia protein (PML) was originally identified as a fusion partner of retinoic
acid receptor alpha in acute promyelocytic leukemia patients with the (15; 17) chromosomal …

Viruses employ a variety of strategies to usurp and control cellular activities through the
orchestrated recruitment of macromolecules to specific cytoplasmic or nuclear …

Kaposi sarcoma herpesvirus (KSHV), taxonomical name human gammaherpesvirus 8, is a
phylogenetically old human virus that co-evolved with human populations, but is now only …

Several pathways have been implicated in the establishment of antiviral state in response to
interferon (IFN), one of which implicates the promyelocytic leukemia (PML) protein. The PML …

Highlights•KSHV/HHV8 causes three human diseases: Kaposi Sarcoma, Primary Effusion
Lymphoma and the plasma cell variant of Multicentric Castleman Disease.•These occur …

Since posttranslational modification (PTM) by the small ubiquitin-related modifiers (SUMOs)
was discovered over a decade ago, a huge number of cellular proteins have been found to …

The crucial function of the PTEN tumor suppressor in multiple cellular processes suggests
that its activity must be tightly controlled. Both, membrane association and a variety of post …

In recent studies we and others have identified the cellular proteins PML, hDaxx, and Sp100,
which form a subnuclear structure known as nuclear domain 10 (ND10) or PML nuclear …

The tripartite motif (TRIM) family comprises at least 80 members in humans, with most
having ubiquitin or SUMO E3 ligase activity conferred by their N-terminal RING domain …

Sumoylation has emerged as a major post-translational modification of cellular proteins,
affecting a variety of cellular processes. Viruses have exploited the sumoylation pathway to …