Cryptosporidium pathogenicity and virulence

M Bouzid, PR Hunter, RM Chalmers… - Clinical microbiology …, 2013 - Am Soc Microbiol
Cryptosporidium is a protozoan parasite of medical and veterinary importance that causes
gastroenteritis in a variety of vertebrate hosts. Several studies have reported different …

Trypanosoma Cruzi Genome: Organization, Multi-Gene Families, Transcription, and Biological Implications

A Herreros-Cabello, F Callejas-Hernández, N Gironès… - Genes, 2020 - mdpi.com
Chagas disease caused by the parasite Trypanosoma cruzi affects millions of people.
Although its first genome dates from 2005, its complexity hindered a complete assembly and …

Multigene families in Trypanosoma cruzi and their role in infectivity

LM De Pablos, A Osuna - Infection and immunity, 2012 - Am Soc Microbiol
The Trypanosoma cruzi genome contains the most widely expanded content (∼ 12,000
genes) of the trypanosomatids sequenced to date. This expansion is reflected in the high …

Genomic assemblies of newly sequenced Trypanosoma cruzi strains reveal new genomic expansion and greater complexity

F Callejas-Hernández, A Rastrojo, C Poveda… - Scientific reports, 2018 - nature.com
Chagas disease is a complex illness caused by the protozoan Trypanosoma cruzi
displaying highly diverse clinical outcomes. In this sense, the genome sequence elucidation …

Genomic Analyses, Gene Expression and Antigenic Profile of the Trans-Sialidase Superfamily of Trypanosoma cruzi Reveal an Undetected Level of Complexity

LM Freitas, SL Dos Santos, GF Rodrigues-Luiz… - Plos one, 2011 - journals.plos.org
The protozoan parasite Trypanosoma cruzi is the etiologic agent of Chagas disease, a
highly debilitating human pathology that affects millions of people in the Americas. The …

Genome evolution in trypanosomatid parasites

AP Jackson - Parasitology, 2015 - cambridge.org
A decade of genome sequencing has transformed our understanding of how trypanosomatid
parasites have evolved and provided fresh impetus to explaining the origins of parasitism in …

Repeat-Driven Generation of Antigenic Diversity in a Major Human Pathogen, Trypanosoma cruzi

C Talavera-López, LA Messenger, MD Lewis… - Frontiers in cellular …, 2021 - frontiersin.org
Trypanosoma cruzi, a zoonotic kinetoplastid protozoan parasite, is the causative agent of
American trypanosomiasis (Chagas disease). Having a very plastic, repetitive and complex …

Telomere and subtelomere R-loops and antigenic variation in trypanosomes

A Saha, VP Nanavaty, B Li - Journal of molecular biology, 2020 - Elsevier
Trypanosoma brucei is a kinetoplastid parasite that causes African trypanosomiasis, which
is fatal if left untreated. T. brucei regularly switches its major surface antigen, VSG, to evade …

Mechanisms of adaptation and evolution in Toxoplasma gondii

SO Angel, L Vanagas, AM Alonso - Molecular and Biochemical …, 2024 - Elsevier
Toxoplasma has high host flexibility, infecting all nucleated cells of mammals and birds. This
implies that during its infective process the parasite must constantly adapt to different …

Anatomy and evolution of telomeric and subtelomeric regions in the human protozoan parasite Trypanosoma cruzi

RR Moraes Barros, MM Marini, CR Antônio, DR Cortez… - BMC genomics, 2012 - Springer
Background The subtelomeres of many protozoa are highly enriched in genes with roles in
niche adaptation. T. cruzi trypomastigotes express surface proteins from Trans-Sialidase …