Chromosomes of eukaryotes adopt highly dynamic and complex hierarchical structures in
the nucleus. The three-dimensional (3D) organization of chromosomes profoundly affects …

Genetic variation associated with disease often appears in non-coding parts of the genome.
Understanding the mechanisms by which this phenomenon leads to disease is necessary to …

Enhancing CRISPR-mediated site-specific transgene insertion efficiency by homology-
directed repair (HDR) using high concentrations of double-stranded DNA (dsDNA) with …

Chimeric antigen receptors (CARs) are synthetic receptors that redirect and reprogram T
cells to mediate tumour rejection. The most successful CARs used to date are those …

Haplotyping of human chromosomes is a prerequisite for cataloguing the full repertoire of
genetic variation. We present a microfluidics-based, linked-read sequencing technology that …

Universal CAR T-cell therapies are poised to revolutionize cancer treatment and to improve
patient outcomes. However, realizing these advantages in an allogeneic setting requires …

Recent studies have identified somatic ESR1 mutations in patients with metastatic breast
cancer and found some of them to promote estrogen-independent activation of the receptor …

Heterozygous mutations in six transfer RNA (tRNA) synthetase genes cause Charcot-Marie-
Tooth (CMT) peripheral neuropathy. CMT mutant tRNA synthetases inhibit protein synthesis …

Structural variants (SVs) can contribute to oncogenesis through a variety of mechanisms.
Despite their importance, the identification of SVs in cancer genomes remains challenging …

Hypoxia is known to be detrimental in cancer and contributes to its development. In this
work, we present an approach to fate-map hypoxic cells in vivo in order to determine their …