Two years after the emergence of SARS-CoV-2, our understanding of COVID-19 disease
pathogenesis is still incomplete. Despite unprecedented global collaborative scientific efforts …

Neutrophils are vital for the innate immune system's control of pathogens and neutrophil
deficiency can render the host susceptible to life-threatening infections. Neutrophil …

Cytosolic proliferating cell nuclear antigen (PCNA) is involved in neutrophil survival and
function, in which it acts as a scaffold and associates with proteins involved in apoptosis …

Apoptosis is central for the maintenance of health. In the immune system, apoptosis
guarantees proper development of immune cells and shutdown of immune reactions by the …

Most protein-coding genes produce multiple protein isoforms; however, these isoforms are
commonly neglected in drug discovery. The expression of protein isoforms can be specific to …

Sepsis is a severe inflammatory disease syndrome caused by the dysregulated host
response to infection. Neutrophils act as the first line of defense against pathogens by …

Genome damage has been related to the induction of autoimmune processes, chronic
inflammation, and apoptosis. Recent studies suggest that some rheumatological diseases …

The definition of autoimmune neutropenias (AIN) has been based on the demonstration of
autoantibodies directed to various epitopes on blood neutrophils. However, this definition is …

Background Cytometric analysis has been commonly used to delineate distinct cell
subpopulations among peripheral blood mononuclear cells by the differential expression of …

Sepsis is a severe inflammatory disease syndrome caused by the dysregulated host
response to infection. Neutrophils act as the first line of defense against pathogens by …