Mitochondria are well known as organelles responsible for the maintenance of cellular
bioenergetics through the production of ATP. Although oxidative phosphorylation may be …

Repeated, episodic bouts of skeletal muscle contraction undertaken frequently as structured
exercise training are a potent stimulus for physiological adaptation in many organs …

Nicotinamide adenine dinucleotide (NAD+) is a coenzyme for redox reactions, making it
central to energy metabolism. NAD+ is also an essential cofactor for non-redox NAD+ …

Hydrogen peroxide (H2O2) is a compound involved in some mammalian reactions and
processes. It modulates and signals the redox metabolism of cells by acting as a messenger …

Appropriate mitochondrial physiology is an essential for health and survival. Cells have
developed unique mechanisms to adapt to stress circumstances and changes in metabolic …

Significance: Antioxidant and redox signaling (ARS) events are regulated by critical
molecules that modulate antioxidants, reactive oxygen species (ROS) or reactive nitrogen …

Mitochondria with structural and functional integrity are essential for maintaining
mitochondrial function and cardiac homeostasis. It is involved in the pathogenesis of many …

Aerobic organisms possess numerous antioxidant enzymatic families, including catalases,
superoxide dismutases (SODs), peroxiredoxins (PRDXs), and glutathione peroxidases …

Acetylation is one of the major post-translational protein modifications in the cell, with
manifold effects on the protein level as well as on the metabolome level. The acetyl group …

Adipose tissue regulates numerous physiological processes, and its dysfunction in obese
humans is associated with disrupted metabolic homeostasis, insulin resistance and type 2 …