This review focuses on the role of the peripheral nervous system in cutaneous biology and
disease. During the last few years, a modern concept of an interactive network between …

Kinins are among the most potent autacoids involved in inflammatory, vascular and pain
processes. These short-lived peptides, including bradykinin, kallidin and T-kinin, are …

Nociceptive signals are generated by peripheral sensory organs called nociceptors, which
are endings of small-diameter nerve fibers responsive to the tissue environment. The myriad …

Kinins are a family of peptides implicated in several pathophysiological events. Most of their
effects are likely mediated by the activation of two G‐protein‐coupled receptors: B1 and B2 …

Many known painkillers are not always effective in the therapy of chronic neuropathic pain
manifested by hyperalgesia and tactile allodynia. The mechanisms underlying neuropathic …

Background and purpose: α‐Humulene and trans‐caryophyllene are sesquiterpene
compounds identified in the essential oil of Cordia verbenacea which display topical and …

The vanilloid receptor (TRPV1) is viewed as a molecular integrator of several nociceptive
stimuli. In the present study, we have investigated the role played by TRPV1 in the …

Kinins are generated within inflammatory tissue microenvironments, where they exert
diverse functions, including cell proliferation, leukocyte activation, cell migration, endothelial …

Cytokines are pluripotent soluble proteins secreted by immune and glial cells and are key
elements in the induction and maintenance of pain. They are categorized as pro …

Within the trigeminal ganglion, crosstalk between neurons and satellite glial cells (SGCs)
contributes to neuronal sensitization and transduction of painful stimuli, including migraine …