Cardiac fibrosis is defined as the imbalance of extracellular matrix (ECM) production and
degradation, thus contributing to cardiac dysfunction in many cardiac pathophysiologic …

AMP-activated protein kinase (AMPK) is a fundamental regulator of energy metabolism,
stress resistance, and cellular proteostasis. AMPK signaling controls an integrated signaling …

The AMP-activated protein kinase (AMPK) was initially identified as the kinase that
phosphorylates the 3-hydroxy 3-methylglutaryl coenzyme A reductase, the rate-limiting …

Obesity is increasing rapidly worldwide and is accompanied by many complications,
including impaired muscle regeneration. The obese condition is known to inhibit AMPK …

Heart failure is a progressive muscular disorder leading to a deterioration of the heart
characterized by a contractile dysfunction and a chronic energy deficit. As a consequence …

Heart failure (HF) is a serious disease with high mortality. The incidence of this disease has
continued to increase over the past decade. All cardiovascular diseases causing dysfunction …

Peroxisome proliferator-activated receptor β/δ (PPARβ/δ) activates AMP-activated protein
kinase (AMPK) and plays a crucial role in glucose and lipid metabolism. Here, we examine …

IL11 initiates fibroblast activation but also causes epithelial cell dysfunction. The
mechanisms underlying these processes are not known. We report that IL11-stimulated …

Metabolic syndrome-associated dyslipidemia is mainly initiated by hepatic overproduction of
the plasma lipoproteins carrying triglycerides. Here we examined the effects of the …

In fibroblasts, TGFβ1 stimulates IL11 upregulation that leads to an autocrine loop of IL11-
dependent pro-fibrotic protein translation. The signaling pathways downstream of IL11 …