[HTML][HTML] Cardiac fibrosis: new insights into the pathogenesis
ZG Ma, YP Yuan, HM Wu, X Zhang… - International journal of …, 2018 - ncbi.nlm.nih.gov
Cardiac fibrosis is defined as the imbalance of extracellular matrix (ECM) production and
degradation, thus contributing to cardiac dysfunction in many cardiac pathophysiologic …
degradation, thus contributing to cardiac dysfunction in many cardiac pathophysiologic …
Age-related changes in AMPK activation: Role for AMPK phosphatases and inhibitory phosphorylation by upstream signaling pathways
A Salminen, K Kaarniranta, A Kauppinen - Ageing research reviews, 2016 - Elsevier
AMP-activated protein kinase (AMPK) is a fundamental regulator of energy metabolism,
stress resistance, and cellular proteostasis. AMPK signaling controls an integrated signaling …
stress resistance, and cellular proteostasis. AMPK signaling controls an integrated signaling …
Activation and signaling by the AMP-activated protein kinase in endothelial cells
B Fisslthaler, I Fleming - Circulation research, 2009 - Am Heart Assoc
The AMP-activated protein kinase (AMPK) was initially identified as the kinase that
phosphorylates the 3-hydroxy 3-methylglutaryl coenzyme A reductase, the rate-limiting …
phosphorylates the 3-hydroxy 3-methylglutaryl coenzyme A reductase, the rate-limiting …
Obesity impairs skeletal muscle regeneration through inhibition of AMPK
Obesity is increasing rapidly worldwide and is accompanied by many complications,
including impaired muscle regeneration. The obese condition is known to inhibit AMPK …
including impaired muscle regeneration. The obese condition is known to inhibit AMPK …
AMPK activation, a preventive therapeutic target in the transition from cardiac injury to heart failure
Heart failure is a progressive muscular disorder leading to a deterioration of the heart
characterized by a contractile dysfunction and a chronic energy deficit. As a consequence …
characterized by a contractile dysfunction and a chronic energy deficit. As a consequence …
AMPK: A therapeutic target of heart failure—not only metabolism regulation
Heart failure (HF) is a serious disease with high mortality. The incidence of this disease has
continued to increase over the past decade. All cardiovascular diseases causing dysfunction …
continued to increase over the past decade. All cardiovascular diseases causing dysfunction …
[HTML][HTML] GDF15 mediates the metabolic effects of PPARβ/δ by activating AMPK
Peroxisome proliferator-activated receptor β/δ (PPARβ/δ) activates AMP-activated protein
kinase (AMPK) and plays a crucial role in glucose and lipid metabolism. Here, we examine …
kinase (AMPK) and plays a crucial role in glucose and lipid metabolism. Here, we examine …
[HTML][HTML] IL11 stimulates ERK/P90RSK to inhibit LKB1/AMPK and activate mTOR initiating a mesenchymal program in stromal, epithelial, and cancer cells
AA Widjaja, S Viswanathan, JGW Ting, J Tan… - IScience, 2022 - cell.com
IL11 initiates fibroblast activation but also causes epithelial cell dysfunction. The
mechanisms underlying these processes are not known. We report that IL11-stimulated …
mechanisms underlying these processes are not known. We report that IL11-stimulated …
The PPARβ/δ activator GW501516 prevents the down-regulation of AMPK caused by a high-fat diet in liver and amplifies the PGC-1α-Lipin 1-PPARα pathway leading …
E Barroso, R Rodríguez-Calvo, L Serrano-Marco… - …, 2011 - academic.oup.com
Metabolic syndrome-associated dyslipidemia is mainly initiated by hepatic overproduction of
the plasma lipoproteins carrying triglycerides. Here we examined the effects of the …
the plasma lipoproteins carrying triglycerides. Here we examined the effects of the …
[HTML][HTML] Molecular dissection of pro-fibrotic IL11 signaling in cardiac and pulmonary fibroblasts
AA Widjaja, S Viswanathan, D Jinrui… - Frontiers in Molecular …, 2021 - frontiersin.org
In fibroblasts, TGFβ1 stimulates IL11 upregulation that leads to an autocrine loop of IL11-
dependent pro-fibrotic protein translation. The signaling pathways downstream of IL11 …
dependent pro-fibrotic protein translation. The signaling pathways downstream of IL11 …