Pulmonary fibrosis is a chronic progressive lung disease that steadily leads to lung
architecture disruption and respiratory failure. The development of pulmonary fibrosis is …

Fibrosis can be defined as a pathological process in which deposition of connective tissue
replaces normal parenchyma. The kidney, like any organ or tissue, can be impacted by this …

Selective removal of senescent cells, or senolytic therapy, has been proposed to be a potent
strategy for overcoming age-related diseases and even for reversing aging. We found that …

Renal fibrosis is now recognized as a main determinant of renal pathology to include
chronic kidney disease. Deposition of pathological matrix in the walls of glomerular …

Renal fibrosis lacks effective nephroprotective drugs in clinical settings due to poor
accumulation of therapeutic agents in damaged kidneys, underscoring the urgent need for …

Aims Tubulointerstitial fibrosis, a frequent complication of chronic kidney disease (CKD) is a
major public health issue. Biochanin A (BCA), an isoflavone, has numerous …

Introduction Primary focal segmental glomerulosclerosis (FSGS), a major cause of end-
stage kidney disease (ESKD) in adolescents and young adults, is attributable to recognized …

Liver fibrosis therapy remains limited due to the inefficiency of drug delivery and
inflammation induced by Kupffer cells. In this study, an exosome–liposome hybrid drug …

Abstract The 8-aryl-, 8-styryl-and 8-arylethynyl substituted 5-methoxyflavones were
synthesized and characterized using a combination of spectroscopic techniques. Single …

Src family kinases (SFKs) are non-receptor tyrosine kinases and play a key role in regulating
signal transduction. The mechanism of SFKs in various tumors has been widely studied, and …