Memory T cells are characterized by their low activation threshold, robust effector functions,
and resistance to conventional immunosuppression and costimulation blockade. Unlike their …

Long-term kidney transplant outcomes remain suboptimal, delineating an unmet medical
need. Although current immunosuppressive therapy in kidney transplant recipients is …

Single-antigen bead (SAB) testing permits reassessment of immunologic risk for kidney
transplantation. Traditionally, high panel reactive antibody (PRA), retransplant and …

T-cell alloimmunity plays a dominant role in allograft rejection. The precise contribution of
naïve and memory T cells to this response however remains unclear. To address this …

Background Blood transfusions have the potential to improve graft survival, induce
sensitization, and transmit infections. Current clinical practice is to minimize transfusions in …

Assessment of donor-specific alloreactive memory/effector T cell responses using an IFN-γ
Elispot assay has been suggested to be a novel immune-monitoring tool for evaluating the …

Identification of biomarkers that assess posttransplant risk is needed to improve long-term
outcomes following heart transplantation. The Clinical Trials in Organ Transplantation …

Currently, acute allograft rejection can only be detected reliably by deterioration of graft
function confirmed by allograft biopsy. A huge drawback of this method of diagnosis is that …

Preformed T-cell immune-sensitization should most likely impact allograft outcome during
the initial period after kidney transplantation, since donor-specific memory T-cells may …

The success of belatacept in late-stage clinical trials inaugurates the arrival of a new class of
immunosuppressants based on costimulatory blockade, an immunosuppression strategy …