Imidazole ring is an important five‐membered aromatic heterocycle widely present in natural
products and synthetic molecules. The unique structural feature of imidazole ring with …

At present more than 250 FDA approved chlorine containing drugs were available in the
market and many pharmaceutically important drug candidates in pre-clinical trials. Thus, it is …

The haemoflagellate protozoan Trypanosoma cruzi (T. cruzi) is the causative agent of
Chagas disease (CD), a potentially life-threatening disease. Little by little, remarkable …

Chagas disease is a neglected tropical disease caused by the protozoan Trypanosoma
cruzi. Currently, only nitroheterocyclic nifurtimox (NFX) and benznidazole (BNZ) are …

Chagas disease (CD) is a centenarian neglected parasitosis caused by the protozoan
Trypanosoma cruzi (T. cruzi). Despite the continuous efforts of many organizations and …

Chagas disease and leishmaniasis are neglected tropical diseases caused by the
protozoan parasites Trypanosoma cruzi and Leishmania spp., respectively. They are among …

The effect of weak intermolecular interactions on the binding affinity between ligand-protein
complexes plays an important role in stabilizing a ligand at the interface of a protein …

It has been over a century since Carlos Chagas discovered the Trypanosoma cruzi (T. cruzi)
as the causative agent of Chagas disease (CD), a neglected tropical disease with several …

In the recent decades, N-heterocycles are widely used as versatile scaffolds for the
development of biologically active compounds and considered as one of the privileged …

Spiroannulation reactions are fundamental and invaluable for the synthesis of spirocyclic
compounds. Presented herein are novel cascade reactions of aryl azomethine imines with …