Breast cancer is the most frequent malignancy in females. Due to its major impact on
population, this disease represents a critical public health problem that requires further …

Inflammatory breast cancer (IBC) is a rare and aggressive disease that accounts for~ 2–4%
of all breast cancers. However, despite its low incidence rate, IBC is responsible for 7–10 …

3D cell culture methods confer a high degree of clinical and biological relevance to in vitro
models. This is specifically the case with the spheroid culture, where a small aggregate of …

When cancer metastasizes to bone, considerable pain and deregulated bone remodelling
occurs, greatly diminishing the possibility of cure. Metastasizing tumour cells mobilize and …

Patient-derived xenograft (PDX) models of a growing spectrum of cancers are rapidly
supplanting long-established traditional cell lines as preferred models for conducting basic …

Breast cancer research is hampered by difficulties in obtaining and studying primary human
breast tissue, and by the lack of in vivo preclinical models that reflect patient tumor biology …

The dissemination of circulating tumor cells (CTCs) requires the Epithelial-to-Mesenchymal
transition (EMT), in which cells lose their epithelial characteristics and acquire more …

The discovery that mesenchymal stem cells (MSCs) are recruited into tumors has led to a
great deal of interest over the past decade in the function of MSCs in tumors. To address …

Mesenchymal stem cells (MSCs) are multipotent stem cells derived from the mesoderm that
give rise to several mesenchymal lineages, including osteoblasts, adipocytes, chondrocytes …

Cancer cells often have increased levels of reactive oxygen species (ROS); however,
acquisition of redox adaptive mechanisms allows for evasion of ROS-mediated death …