In conjunction with the endothelin (ET) type A (ETAR) and type B (ETBR) receptors,
angiotensin (AT) type 1 (AT1R) and type 2 (AT2R) receptors, are peptide-binding class A G …

We studied the clinical, histologic, and molecular features distinguishing DSA-negative from
DSA-positive molecularly defined antibody-mediated rejection (mABMR). We analyzed …

Systemic sclerosis (SSc) is a rare connective tissue disorder characterized by immune
dysregulation evoking the pathophysiological triad of inflammation, fibrosis and …

Objective To determine contributions and functions of autoantibodies (Abs) directed to the
angiotensin receptor type 1 (AT1R), which are suggested to be involved in the pathogenesis …

Antibody-mediated rejection (ABMR) is associated with poor transplant outcomes and was
identified as a leading cause of graft failure after kidney transplantation. Although the …

Functional non-HLA antibodies (antibodies to non-human leukocyte antigens) targeting the
G protein-coupled receptors angiotensin II type 1 receptor (AT1R) and endothelin-1 type A …

Histologic antibody-mediated rejection (hAMR) is defined as a kidney allograft biopsy
satisfying the first 2 Banff criteria for diagnosing AMR: tissue injury and evidence of …

The polymorphic human leukocyte antigen (HLA) system has been considered the main
target for alloimmunity, but the non-HLA antibodies and autoimmunity have gained …

Background Anti-angiotensin II type 1 receptor antibodies (AT1R-Abs) have been
recognized as non-human leukocyte antigen antibodies associated with allograft rejection …

Defined as histologic evidence of rejection on a protocol biopsy in the absence of kidney
dysfunction, subclinical rejection has garnered attention since the 1990s. The major focus of …