Cardiac arrhythmias are among the leading causes of mortality. They often arise from
alterations in the electrophysiological properties of cardiac cells and their underlying ionic …

Patient-specific cardiac models are now being used to guide therapies. The increased use
of patient-specific cardiac simulations in clinical care will give rise to the development of …

The human heart beats as a result of multiscale nonlinear dynamics coupling subcellular to
whole organ processes, achieving electrophysiologically-driven mechanical contraction …

In cardiac electrophysiology, there exist many sources of inter-and intra-personal variability.
These include variability in conditions and environment, and genotypic and molecular …

The best pharmacological treatment for each atrial fibrillation (AF) patient is unclear. We aim
to exploit AF simulations in 800 virtual atria to identify key patient characteristics that guide …

Atrial fibrillation (AF) inducibility, sustainability and response to pharmacological treatment of
individual patients are expected to be determined by their ionic current properties, especially …

Aims Cardiac electrophysiological heterogeneity includes:(i) regional differences in action
potential (AP) waveform,(ii) AP waveform differences in cells isolated from a single …

Early detection of coronary heart disease (CHD) has the potential to prevent the millions of
deaths that this disease causes worldwide every year. However, there exist few automatic …

Mechanisms of atrial fibrillation and the susceptibility to reentries can be impacted by the
repolarization across the atria. Studies into atrial fibrillation ignore cell-to-cell heterogeneity …

Prediction of drug effects on the heart still represents a challenge in drug development,
given potential adverse outcomes. Computer modelling and simulations of the human heart …