The gut and lungs are anatomically distinct, but potential anatomic communications and
complex pathways involving their respective microbiota have reinforced the existence of a …

Gut microbiota has a significant role in gut development, maturation, and immune system
differentiation. It exerts considerable effects on the child's physical and mental development …

Although the notion that “the normal lung is free from bacteria” remains common in
textbooks, it is virtually always stated without citation or argument. The lungs are constantly …

Background The airways of patients with cystic fibrosis (CF) are highly complex, subject to
various environmental conditions as well as a distinct microbiota. Pseudomonas aeruginosa …

Background Chronic infection and concomitant airway inflammation is the leading cause of
morbidity and mortality for people living with cystic fibrosis (CF). Although chronic infection in …

The development of culture-independent techniques for microbiological analysis has
uncovered the previously unappreciated complexity of the bacterial microbiome at various …

The type VI secretion system (T6SS) mediates interactions between a broad range of Gram-
negative bacterial species. Recent studies have led to a substantial increase in the number …

Culture-independent microbiological techniques have shown a previously unappreciated
complexity to the bacterial microbiome of the respiratory tract that forces reconsideration of …

Rationale: Ivacaftor is a cystic fibrosis transmembrane conductance regulator (CFTR)
potentiator recently approved for patients with CF age 6 and older with the G551D mutation …

Humans are essentially sterile during gestation, but during and after birth, every body
surface, including the skin, mouth, and gut, becomes host to an enormous variety of …