Challenges of combination therapy with immune checkpoint inhibitors for hepatocellular carcinoma

AL Cheng, C Hsu, SL Chan, SP Choo, M Kudo - Journal of hepatology, 2020 - Elsevier
Immune checkpoint inhibitor (ICI) therapy targeting anti-programmed cell death-1 (anti-PD-
1) or its ligand (anti-PD-L1) is the backbone of numerous combination regimens aimed at …

Immune checkpoint inhibitor combinations: Current efforts and important aspects for success

E Kon, I Benhar - Drug Resistance Updates, 2019 - Elsevier
Immune checkpoint inhibitors (ICI) have emerged as a remarkable treatment option for
diverse cancer types. Currently, ICIs are approved for an expanding array of cancer …

An immune-related gene signature for predicting survival and immunotherapy efficacy in hepatocellular carcinoma

Y Dai, W Qiang, K Lin, Y Gui, X Lan, D Wang - Cancer Immunology …, 2021 - Springer
Background Hepatocellular carcinoma (HCC) ranks the fourth in terms of cancer-related
mortality globally. Herein, in this research, we attempted to develop a novel immune-related …

[HTML][HTML] ATR inhibitor AZD6738 enhances the antitumor activity of radiotherapy and immune checkpoint inhibitors by potentiating the tumor immune microenvironment …

H Sheng, Y Huang, Y Xiao, Z Zhu, M Shen… - … for immunotherapy of …, 2020 - ncbi.nlm.nih.gov
Background Radioimmunotherapy has a promising antitumor effect in hepatocellular
carcinoma (HCC), depending on the regulatory effect of radiotherapy on tumor immune …

[HTML][HTML] Immune checkpoint inhibitors in hepatocellular carcinoma: current progresses and challenges

HT Liu, MJ Jiang, ZJ Deng, L Li, JL Huang… - Frontiers in …, 2021 - frontiersin.org
Hepatocellular carcinoma (HCC) is one of the most common malignant tumor in the world
and its incidence is increasing in many countries. In recent years, with the deepening …

Angiogenesis and immune checkpoint dual blockade in combination with radiotherapy for treatment of solid cancers: opportunities and challenges

L Zhu, X Yu, L Wang, J Liu, Z Qu, H Zhang, L Li, J Chen… - Oncogenesis, 2021 - nature.com
Several immune checkpoint blockades (ICBs) capable of overcoming the
immunosuppressive roles of the tumor immune microenvironment have been approved by …

Evidences of CTLA-4 and PD-1 blocking agents-induced cardiotoxicity in cellular and preclinical models

V Quagliariello, M Passariello, D Rea… - Journal of Personalized …, 2020 - mdpi.com
Background: Several strategies based on immune checkpoint inhibitors (ICIs) have been
developed for cancer therapy, opening to advantages in cancer outcomes. However, several …

[HTML][HTML] Tumor-associated macrophages in hepatocellular carcinoma: friend or foe?

D Zhou, J Luan, C Huang, J Li - Gut and Liver, 2021 - ncbi.nlm.nih.gov
Hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide, and it
has diverse etiologies with multiple mechanisms. The diagnosis of HCC typically occurs at …

Sonodynamic therapy complements PD-L1 immune checkpoint inhibition in a murine model of pancreatic cancer

H Nesbitt, K Logan, K Thomas, B Callan, J Gao… - Cancer Letters, 2021 - Elsevier
The emergence of immune checkpoint inhibitors (ICI's) in the past decade has proven
transformative in the area of immuno-oncology. The PD-1/PD-L1 axis has been particularly …

Incorporating sarcopenia and inflammation with radiation therapy in patients with hepatocellular carcinoma treated with nivolumab

N Kim, JI Yu, HC Park, GS Yoo, C Choi… - Cancer Immunology …, 2021 - Springer
Background We investigated the combined effects of sarcopenia and inflammation on
outcomes in patients with HCC treated with nivolumab. Materials and Methods We reviewed …