Challenges of combination therapy with immune checkpoint inhibitors for hepatocellular carcinoma
Immune checkpoint inhibitor (ICI) therapy targeting anti-programmed cell death-1 (anti-PD-
1) or its ligand (anti-PD-L1) is the backbone of numerous combination regimens aimed at …
1) or its ligand (anti-PD-L1) is the backbone of numerous combination regimens aimed at …
Immune checkpoint inhibitor combinations: Current efforts and important aspects for success
Immune checkpoint inhibitors (ICI) have emerged as a remarkable treatment option for
diverse cancer types. Currently, ICIs are approved for an expanding array of cancer …
diverse cancer types. Currently, ICIs are approved for an expanding array of cancer …
An immune-related gene signature for predicting survival and immunotherapy efficacy in hepatocellular carcinoma
Background Hepatocellular carcinoma (HCC) ranks the fourth in terms of cancer-related
mortality globally. Herein, in this research, we attempted to develop a novel immune-related …
mortality globally. Herein, in this research, we attempted to develop a novel immune-related …
[HTML][HTML] ATR inhibitor AZD6738 enhances the antitumor activity of radiotherapy and immune checkpoint inhibitors by potentiating the tumor immune microenvironment …
H Sheng, Y Huang, Y Xiao, Z Zhu, M Shen… - … for immunotherapy of …, 2020 - ncbi.nlm.nih.gov
Background Radioimmunotherapy has a promising antitumor effect in hepatocellular
carcinoma (HCC), depending on the regulatory effect of radiotherapy on tumor immune …
carcinoma (HCC), depending on the regulatory effect of radiotherapy on tumor immune …
[HTML][HTML] Immune checkpoint inhibitors in hepatocellular carcinoma: current progresses and challenges
HT Liu, MJ Jiang, ZJ Deng, L Li, JL Huang… - Frontiers in …, 2021 - frontiersin.org
Hepatocellular carcinoma (HCC) is one of the most common malignant tumor in the world
and its incidence is increasing in many countries. In recent years, with the deepening …
and its incidence is increasing in many countries. In recent years, with the deepening …
Angiogenesis and immune checkpoint dual blockade in combination with radiotherapy for treatment of solid cancers: opportunities and challenges
L Zhu, X Yu, L Wang, J Liu, Z Qu, H Zhang, L Li, J Chen… - Oncogenesis, 2021 - nature.com
Several immune checkpoint blockades (ICBs) capable of overcoming the
immunosuppressive roles of the tumor immune microenvironment have been approved by …
immunosuppressive roles of the tumor immune microenvironment have been approved by …
Evidences of CTLA-4 and PD-1 blocking agents-induced cardiotoxicity in cellular and preclinical models
V Quagliariello, M Passariello, D Rea… - Journal of Personalized …, 2020 - mdpi.com
Background: Several strategies based on immune checkpoint inhibitors (ICIs) have been
developed for cancer therapy, opening to advantages in cancer outcomes. However, several …
developed for cancer therapy, opening to advantages in cancer outcomes. However, several …
[HTML][HTML] Tumor-associated macrophages in hepatocellular carcinoma: friend or foe?
D Zhou, J Luan, C Huang, J Li - Gut and Liver, 2021 - ncbi.nlm.nih.gov
Hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide, and it
has diverse etiologies with multiple mechanisms. The diagnosis of HCC typically occurs at …
has diverse etiologies with multiple mechanisms. The diagnosis of HCC typically occurs at …
Sonodynamic therapy complements PD-L1 immune checkpoint inhibition in a murine model of pancreatic cancer
H Nesbitt, K Logan, K Thomas, B Callan, J Gao… - Cancer Letters, 2021 - Elsevier
The emergence of immune checkpoint inhibitors (ICI's) in the past decade has proven
transformative in the area of immuno-oncology. The PD-1/PD-L1 axis has been particularly …
transformative in the area of immuno-oncology. The PD-1/PD-L1 axis has been particularly …
Incorporating sarcopenia and inflammation with radiation therapy in patients with hepatocellular carcinoma treated with nivolumab
Background We investigated the combined effects of sarcopenia and inflammation on
outcomes in patients with HCC treated with nivolumab. Materials and Methods We reviewed …
outcomes in patients with HCC treated with nivolumab. Materials and Methods We reviewed …