Helicobacter pylori Virulence Factors—Mechanisms of Bacterial Pathogenicity in the Gastric Microenvironment

J Baj, A Forma, M Sitarz, P Portincasa, G Garruti… - Cells, 2020 - mdpi.com
Gastric cancer constitutes one of the most prevalent malignancies in both sexes; it is
currently the fourth major cause of cancer-related deaths worldwide. The pathogenesis of …

Helicobacter pylori and Its Role in Gastric Cancer

VE Reyes - Microorganisms, 2023 - mdpi.com
Gastric cancer is a challenging public health concern worldwide and remains a leading
cause of cancer-related mortality. The primary risk factor implicated in gastric cancer …

Helicobacter pylori VacA Targets Myeloid Cells in the Gastric Lamina Propria To Promote Peripherally Induced Regulatory T-Cell Differentiation and Persistent …

A Altobelli, M Bauer, K Velez, TL Cover, A Müller - MBio, 2019 - Am Soc Microbiol
The gastric bacterium Helicobacter pylori causes a persistent infection that is directly
responsible for gastric ulcers and gastric cancer in some patients and protective against …

Respiratory heterogeneity shapes biofilm formation and host colonization in uropathogenic Escherichia coli

CJ Beebout, AR Eberly, SH Werby, SA Reasoner… - MBio, 2019 - Am Soc Microbiol
Biofilms are multicellular bacterial communities encased in a self-secreted extracellular
matrix comprised of polysaccharides, proteinaceous fibers, and DNA. Organization of these …

Mechanisms of persistence, innate immune activation and immunomodulation by the gastric pathogen Helicobacter pylori

X Zhang, IC Arnold, A Müller - Current opinion in microbiology, 2020 - Elsevier
The gastric bacterium Helicobacter pylori efficiently evades innate immune detection and
persistently colonizes its human host. Understanding the genetic determinants that H. pylori …

[HTML][HTML] Helicobacter pylori gamma-glutamyl transpeptidase and its pathogenic role

V Ricci, M Giannouli, M Romano… - World journal of …, 2014 - ncbi.nlm.nih.gov
Helicobacter pylori (H. pylori) gamma-glutamyl transpeptidase (GGT) is a bacterial virulence
factor that converts glutamine into glutamate and ammonia, and converts glutathione into …

[HTML][HTML] Association between Helicobacter spp. infections and hepatobiliary malignancies: a review

FK Segura-López, A Güitrón-Cantú… - World Journal of …, 2015 - ncbi.nlm.nih.gov
Hepatobiliary cancers are highly lethal cancers that comprise a spectrum of invasive
carcinomas originating in the liver hepatocellular carcinoma, the bile ducts intrahepatic …

[HTML][HTML] Metabolism of glutathione S-conjugates: multiple pathways

AJL Cooper, MH Hanigan - Comprehensive toxicology, 2018 - ncbi.nlm.nih.gov
Many potentially toxic electrophilic xenobiotics and some endogenous compounds are
detoxified by conversion to the corresponding glutathione S-conjugate, which is metabolized …

Pathogenesis of Helicobacter pylori Infection

RM Delahay, M Rugge - Helicobacter, 2012 - Wiley Online Library
Although H elicobacter pylori infection is highly prevalent in the global human population,
the majority of infected individuals remain asymptomatic. A complex combination of host …

Helicobacter pylori γ-glutamyltranspeptidase induces tolerogenic human dendritic cells by activation of glutamate receptors

R Käbisch, RP Semper, S Wüstner… - The Journal of …, 2016 - journals.aai.org
Helicobacter pylori infection is characterized by chronic persistence of the bacterium.
Different virulence factors, including H. pylori γ-glutamyltranspeptidase (gGT), have been …