Successful regeneration of weight‐bearing bone defects and critical‐sized cartilage defects
remains a major challenge in clinical orthopedics. In the past decades, biodegradable …

Ceramic bone implants have potential properties ideal for long-term implantation
applications. On comparison with other materials, ceramic biomaterials have advantages …

An osteochondral scaffold has a chondrogenic spiral scaffold in one end of an outer shell
made of sintered microspheres, and an osteogenic spiral scaffold in the other end of the …

Background Mesenchymal stem cell (MSC)-derived exosomes have been recognized as
new candidate agents for treating critical-sized bone defects; they promote angiogenesis …

Bone vasculature plays a vital role in bone development, remodeling and homeostasis. New
blood vessel formation is crucial during both primary bone development as well as fracture …

The lack of a functional vascular supply has, to a large extent, hampered the whole range of
clinical applications of 'successful'laboratory‐based bone tissue engineering strategies. To …

Biomaterials are employed in the fields of tissue engineering and regenerative medicine
(TERM) in order to enhance the regeneration or replacement of tissue function and/or …

Significant advances have been made in bone tissue engineering (TE) in the past decade.
However, classical bone TE strategies have been hampered mainly due to the lack of …

Steroid-induced osteonecrosis of the femoral head (SONFH) is a disease characterized by
the collapse of the femoral head. SONFH occurs due to the overuse of glucocorticoids (GCs) …

The porous architectural characteristics of biomaterials play an important role in scaffold
revascularization. However, no consensus exists regarding optimal interconnection sizes for …