The glycoprotein osteopontin (OPN) possesses multiple functions in health and disease. To
this end, osteopontin has beneficial roles in wound healing, bone homeostasis, and …

Small cell lung cancer (SCLC) is an aggressive malignancy that includes subtypes defined
by differential expression of ASCL1, NEUROD1, and POU2F3 (SCLC-A,-N, and-P …

The lung tumor microenvironment, which is composed of heterogeneous cell populations,
plays an important role in the progression of lung cancer and is closely related to therapeutic …

Glioblastoma is highly enriched with macrophages, and osteopontin (OPN) expression
levels correlate with glioma grade and the degree of macrophage infiltration; thus, we …

Malignant pleural effusion (MPE) is the lethal consequence of various human cancers
metastatic to the pleural cavity. However, the mechanisms responsible for the development …

Lung adenocarcinoma (LUAD)-derived Wnts increase cancer cell proliferative/stemness
potential, but whether they impact the immune microenvironment is unknown. Here we show …

Objective Tumor metastasis is still a great challenge for the prognosis of colorectal cancer
(CRC). Although secreted phosphoprotein 1 (SPP1) over-expression is confirmed to …

Chemotherapy is one of the most important approaches for the treatment of various cancers.
However, tumor cells often develop resistance to chemotherapeutic drugs. The tumor …

The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused the
ongoing coronavirus disease 2019 (COVID-19) pandemic, with more than 50 million cases …

Although oncogenic activation of NFκB has been identified in various tumors, the NFκB–
activating kinases (inhibitor of NFκB kinases, IKK) responsible for this are elusive. In this …