Positive affect systematically influences performance on many cognitive tasks. A new
neuropsychological theory is proposed that accounts for many of these effects by assuming …

A novel mechanism for regulating dopamine activity in subcortical sites and its possible
relevance to schizophrenia is proposed. This hypothesis is based on the regulation of …

Earlier efforts to localize the symptoms of schizophrenia in a single brain region have been
replaced by models that postulate a disruption in parallel distributed or dynamic circuits …

Connectionist models are used to explore the relationship between cognitive deficits and
biological abnormalities in schizophrenia. Schizophrenic deficits in tasks that tap attention …

• Using positron emission tomography, we studied cerebral glucose metabolism in drug-free,
age-and sex-matched, righthanded patients with unipolar depression (n= 10), bipolar …

The cognitive symptoms of schizophrenia are largely resistant to current treatment and are
thus a life-long burden of the illness. Studies of cognitive symptoms have commonly focused …

The effects of the indolehallucinogen psilocybin, a mixed 5-HT 2 and 5-HT 1 agonist, on
regional cerebral glucose metabolism were investigated in 10 healthy volunteers with PET …

Of all mental health disorders, schizophrenia remains the most pervasive, bewildering, and
resistant to treatment. In addition to its profound effect on the patient, the illness can be …

Background: In the past two decades, gross morphologic changes have been uncovered in
the schizophrenic brain, eg, increased ventricular width and decreased cortical volume; …

Clinical and experimental research have provided anatomical, pharmacological, and
behavioral evidence for a prominent prefrontal dysfunction in schizophrenia. Negative …