Glioma represents a dominant primary intracranial malignancy in the central nervous
system. Artificial intelligence that mainly includes machine learning, and deep learning …

The contributions of cooperative groups to performing large-cohort clinical trials and long-
term survivorship studies have facilitated advances in treatment, supportive care and …

Purpose Two phase II studies assessed the efficacy of vismodegib, a sonic hedgehog (SHH)
pathway inhibitor that binds smoothened (SMO), in pediatric and adult recurrent …

Recent research has demonstrated that survivors of childhood cancer are at risk for a myriad
of late effects that affect physical and mental quality of life. We discuss the patterns and …

The nuclear genome decays as organisms age. Numerous studies demonstrate that the
burden of several classes of DNA lesions is greater in older mammals than in young …

Background Compared with traditional photon radiotherapy, proton radiotherapy irradiates
less normal tissue and might improve health outcomes associated with photon radiotherapy …

This report provides a review of early and late effects of radiation in normal tissues and
organs with respect to radiation protection. It was instigated following a recommendation in …

Abstract On March 16, 2023, the FDA approved dabrafenib in combination with trametinib
(Tafinlar, Mekinist; Novartis Pharmaceuticals Corporation) for the treatment of pediatric …

Although significant improvements have been made in the outcomes of children with cancer,
the pace of improvement has slowed in recent years as the limits of therapy intensification …

Abstract Characterization of toxicity associated with cancer and its treatment is essential to
quantify risk, inform optimization of therapeutic approaches for newly diagnosed patients …