Because of a preconceived notion that eliminating reactive metabolite (RM) formation with
new drug candidates could mitigate the risk of idiosyncratic drug toxicity, the potential for RM …

Quinones and quinone imines are highly reactive metabolites (RMs) able to induce
dangerous effects in vivo. They are responsible for all kinds of toxicity, for example …

Featuring more than 4100 references, Drug-Induced Liver Disease is an invaluable
reference for gastroenterologists, hepatologists, family physicians, internists, pathologists …

Introduction: Carbamazepine (CBZ) is used for the treatment of epilepsy and other
neurological and psychiatric disorders. The occurrence of adverse reactions (ADRs) to CBZ …

Carbamazepine (CBZ) is a pharmaceutical frequently categorized as a recalcitrant pollutant
in the aquatic environment. Endophytic bacteria previously isolated from reed plants have …

Drug-induced liver injury includes a spectrum of pathologies, some related to the mode of
injury, some to the cell type primarily damaged. Among these, drug-induced bile duct injury …

It is generally believed that metabolic bioactivation of drug molecules to form reactive
metabolites, followed by their covalent binding to endogenous macromolecules, is one of …

Aim: The aim of this study was to evaluate the association of genetic variants in the major
genes involved in carbamazepine (CBZ) metabolism and transport with its pharmacokinetics …

The widely used anticonvulsant pharmaceutical carbamazepine is recalcitrant in many
environmental niches and thus poses a challenge in wastewater treatment. We followed the …

The present study describes a new analytical approach for the detection and
characterization of GSH-trapped reactive metabolites using multiple reaction monitoring …