Dysregulation of the endogenous lipid mediators endocannabinoids and their G-protein-
coupled cannabinoid receptors 1 and 2 (CB1R and CB2R) has been implicated in a variety …

In an increasing number of states and countries, cannabis now stands poised to join alcohol
and tobacco as a legal drug. Quantifying the relative adverse and beneficial effects of …

The discovery of the endocannabinoid system, comprising the G‐protein coupled
cannabinoid 1 and 2 receptors (CB 1/2), their endogenous lipid ligands or …

Simple Summary Our understanding of the Endocannabinoid System of animals, and its
ubiquitous presence in nearly all members of Animalia, has opened the door to novel …

Cannabis remains the most commonly used and trafficked illicit drug in the world. Its use is
largely concentrated among young people (15-to 34-year-olds). There is a variety of …

Objective: To determine the safety and tolerability of escalating doses of three cannabis oil
formulations, containing predominantly CBD, THC, or CBD and THC (1.5: 1) vs. placebo in …

To review and summarise the literature reporting on cannabis use within western
communities with specific reference to patterns of use, the pharmacology of its major …

Cannabis has the potential to modulate some of the most common and debilitating
symptoms of cancer and its treatments, including nausea and vomiting, loss of appetite, and …

Inflammasomes are cytoplasmic inflammatory signaling protein complexes that detect
microbial materials, sterile inflammatory insults, and certain host-derived elements …

As perspectives on cannabis continue to shift, understanding the physiological and
behavioral effects of cannabis use is of paramount importance. Previous data suggest that …