Best practices in preclinical algesiometry (pain behaviour testing) have shifted over the past
decade as a result of technological advancements, the continued dearth of translational …

This narrative review represents an output from the International Association for the Study of
Pain's global task force on the use of cannabis, cannabinoids, and cannabis-based …

The so-called 'replicability crisis' has sparked methodological discussions in many areas of
science in general, and in psychology in particular. This has led to recent endeavours to …

Nonsuicidal self-injury (NSSI) is a serious clinical problem, particularly for adolescents and
young adults. NSSI is a complex behavior that emerges through the intersecting effects of …

Placebo effects are beneficial effects that are attributable to the brain–mind responses to the
context in which a treatment is delivered rather than to the specific actions of the drug. They …

The motivation to avoid pain and injury is a fundamental instinct, crucial to the survival of
individuals and species. Yet, each year, millions of people purposefully and directly injure …

The nature of the transition from acute to chronic pain still eludes explanation, but chronic
pain resulting from surgery provides a natural experiment that invites clinical …

Chronic pain states are highly prevalent and yet poorly controlled by currently available
analgesics, representing an enormous clinical, societal, and economic burden. Existing pain …

Pain thresholds are, in part, set as a function of emotional and internal states by descending
modulation of nociceptive transmission in the spinal cord. Neurons of the rostral …

General anesthesia (GA) can produce analgesia (loss of pain) independent of inducing loss
of consciousness, but the underlying mechanisms remain unclear. We hypothesized that GA …