Durlobactam, a New Diazabicyclooctane β-Lactamase Inhibitor for the Treatment of Acinetobacter Infections in Combination With Sulbactam

AB Shapiro, SH Moussa, SM McLeod… - Frontiers in …, 2021 - frontiersin.org
Durlobactam is a new member of the diazabicyclooctane class of β-lactamase inhibitors with
broad spectrum activity against Ambler class A, C, and D serine β-lactamases. Sulbactam is …

Molecular Characterization of Carbapenem-Resistant Acinetobacter baumannii with Special Reference to Carbapenemases: A Systematic Review

N Gupta, K Angadi, S Jadhav - Infection and Drug Resistance, 2022 - Taylor & Francis
Carbapenemases are β-lactamase enzymes that hydrolyze a variety of β-lactams including
carbapenem and belong to different Ambler classes (A, B, D). These enzymes can be …

In Vitro Activity of Sulbactam-Durlobactam against Global Isolates of Acinetobacter baumannii-calcoaceticus Complex Collected from 2016 to 2021

JA Karlowsky, MA Hackel, SM McLeod… - Antimicrobial Agents …, 2022 - Am Soc Microbiol
Sulbactam-durlobactam is a β-lactam-β-lactamase inhibitor combination designed to treat
serious Acinetobacter baumannii-calcoaceticus complex (ABC) infections, including …

Clinical Outcomes and Bacterial Characteristics of Carbapenem-resistant Acinetobacter baumannii Among Patients From Different Global Regions

M Wang, L Ge, L Chen, L Komarow… - Clinical Infectious …, 2024 - academic.oup.com
Abstract Background Carbapenem-resistant Acinetobacter baumannii (CRAb) is 1 of the
most problematic antimicrobial-resistant bacteria. We sought to elucidate the international …

[HTML][HTML] Comparative genomics and molecular epidemiology of colistin-resistant Acinetobacter baumannii

J Kabic, K Novovic, D Kekic, A Trudic, N Opavski… - Computational and …, 2023 - Elsevier
This study aimed to investigate the prevalence and resistance mechanisms of colistin-
resistant Acinetobacter baumannii (ColRAB) isolates in Serbia, assess their genetic …

Whole-Genome Sequencing of ST2 A. baumannii Causing Bloodstream Infections in COVID-19 Patients

S Cherubini, M Perilli, B Segatore, P Fazii, G Parruti… - Antibiotics, 2022 - mdpi.com
A total of 43 A. baumannii strains, isolated from 43 patients affected by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) and by bacterial sepsis, were analyzed …

[HTML][HTML] Whole-genome analysis of carbapenem-resistant Acinetobacter baumannii from clinical isolates in Southern Thailand

A Chukamnerd, K Singkhamanan… - Computational and …, 2022 - Elsevier
The worldwide spread of carbapenem-resistant Acinetobacter baumannii (CRAB) has
become a healthcare challenge for some decades. To understand its molecular …

Phenotypic and Molecular Characteristics of Carbapenem-Resistant Acinetobacter baumannii Isolates from Bulgarian Intensive Care Unit Patients

TV Strateva, I Sirakov, TJ Stoeva, A Stratev, S Peykov - Microorganisms, 2023 - mdpi.com
Carbapenem-resistant Acinetobacter baumannii (CRAB) is designated as an urgent public
health threat, both due to its remarkable multidrug resistance and propensity for clonal …

The evolutionary tale of eight novel plasmids in a colistin-resistant environmental Acinetobacter baumannii isolate

FT Prity, LA Tobin, R Maharajan… - Microbial …, 2023 - microbiologyresearch.org
Acinetobacter baumannii is an important opportunistic pathogen known for its high levels of
resistance to many antibiotics, particularly those considered last resorts such as colistin and …

Whole-genome sequencing-based resistome analysis of nosocomial multidrug-resistant non-fermenting Gram-negative pathogens from the Balkans

S Peykov, T Strateva - Microorganisms, 2023 - mdpi.com
Non-fermenting Gram-negative bacilli (NFGNB), such as Pseudomonas aeruginosa and
Acinetobacter baumannii, are among the major opportunistic pathogens involved in the …