Epigenetic inheritance is another piece of the puzzle of nongenetic inheritance, although the
prevalence, sources, persistence, and phenotypic consequences of heritable epigenetic …

CBP/p300, functioning as histone acetyltransferases and transcriptional co-factors,
represents an attractive target for various diseases, including malignant tumor. The …

Diabetes mellitus (DM) is an important risk factor for dementia, which is a common
neurodegenerative disorder. DM is known to activate inflammation, oxidative stress, and …

Decades of research have sought to determine the intrinsic and extrinsic mechanisms
underpinning the regulation of neural progenitor maintenance and differentiation. A series of …

Abstract Background Neural tube defects (NTDs) are severe congenital malformations.
Diabetes during pregnancy is a risk factor for NTDs, but its mechanism remains elusive …

Aims Direct cardiac reprogramming represents an attractive way to reversing heart damage
caused by myocardial infarction because it removes fibroblasts, while also generating new …

Abstract p300/CBP bromodomain plays an important role in transcriptional regulation, and
its overexpression is closely related to various diseases such as cancers. Two inhibitors of …

Background Gut microbiota and their metabolites play a regulatory role in skeletal muscle
growth and development, which be known as gut-muscle axis. 3-phenylpropionic acid (3 …

Introduction: Neural tube defects (NTDs) are serious congenital malformations. The etiology
of NTDs involves both genetic and environmental factors. Loss of CECR2 in mice has been …

Abstract Background Neural tube defects (NTDs) are severe common birth defects that result
from a failure in neural tube closure (NTC). Our previous study has shown that decreased …