Motivation Methods that estimate the quality of a 3D protein structure model in absence of an
experimental reference structure are crucial to determine a model's utility and potential …

The structural variability data of drug transporter (DT) are key for research on precision
medicine and rational drug use. However, these valuable data are not sufficiently covered …

Abstract SARS-CoV-2 membrane (M) protein performs a variety of critical functions in virus
infection cycle. However, the expression and purification of membrane protein structure is …

Methods to reliably estimate the accuracy of 3D models of proteins are both a fundamental
part of most protein folding pipelines and important for reliable identification of the best …

Shigella spp. are the leading bacterial cause of severe childhood diarrhoea in low-and
middle-income countries (LMICs), are increasingly antimicrobial resistant and have no …

The 'structure assessment'web server is a one-stop shop for interactive evaluation and
benchmarking of structural models of macromolecular complexes including proteins and …

Transfer RNA (tRNA) molecules are essential to decode messenger RNA codons during
protein synthesis. All known tRNAs are heavily modified at multiple positions through post …

The recent emergence of the novel coronavirus (SARS-CoV-2) has raised global concern as
it is declared a pandemic by the WHO. However, to date, there is no current regimen to …

Genetic and bioinformatic analyses have identified missense mutations in GRIN2B encoding
the NMDA receptor GluN2B subunit in autism, intellectual disability, Lennox Gastaut and …

Physiological nucleosides are used for the synthesis of DNA, RNA, and ATP in the cell and
serve as universal mammalian signaling molecules that regulate physiological processes …