The mammalian Rel/NF-κB family of transcription factors, including RelA, c-Rel, RelB, NF-
κB1 (p50 and its precursor p105), and NF-κB2 (p52 and its precursor p100), plays a central …

Nuclear factor of κB (NF-κB) is a sequence-specific transcription factor that is known to be
involved in the inflammatory and innate immune responses. Although the importance of NF …

RNA aptamers and RNA aptamer-based devices can be genetically encoded and
expressed in cells to probe and manipulate cellular function. However, their usefulness in …

NF-κB transcription factors have been suspected to be involved in cancer development
since their discovery because of their kinship with the v-Rel oncogene product. Subsequent …

Kaposi sarcoma (KS) herpesvirus (KSHV), also known as human herpesvirus 8, is the
causal agent of KS but is also pathogenetically related to several lymphoproliferative …

An effective host defense mechanism involves inflammation to eliminate pathogens from the
site of infection, followed by the resolution of inflammation and the restoration of tissue …

Abstract The Ras/Raf/Mitogen-activated protein kinase/ERK kinase (MEK)/extracellular-
signal-regulated kinase (ERK) cascade couples signals from cell surface receptors to …

We have shown that thalidomide (Thal) and its immunomodulatory derivatives (IMiDs),
proteasome inhibitor PS-341, and As 2 O 3 act directly on multiple myeloma (MM) cells and …

Kaposi's sarcoma-associated herpesvirus (KSHV) is associated with three malignancies—
Kaposi's sarcoma (KS), primary effusion lymphoma (PEL), and multicentric Castleman's …

Kaposi sarcoma–associated herpesvirus (KSHV), also known as human herpesvirus 8, is
the etiologic agent underlying Kaposi sarcoma, primary effusion lymphoma, and multicentric …