Pharmacokinetics (PK) is the study of the absorption, distribution, metabolism, and excretion
(ADME) processes of a drug. Understanding PK properties is essential for drug development …

Environmental exposures to hazardous chemicals are associated with a variety of human
diseases and disorders, including cancers. Phase I metabolic activation and detoxification …

Cadmium (Cd) is a nephrotoxic environmental pollutant that causes a generalized
dysfunction of the proximal tubule characterized by polyuria and proteinuria. Even though …

The field of epitranscriptome, posttranscriptional modifications to RNAs, is still growing up
and has presented substantial evidences for the role of RNA modifications in diseases. In …

In conditions of acute and chronic inflammation hepatic detoxification capacity is severely
impaired due to coordinated downregulation of drug metabolizing enzymes and …

The alcohol dehydrogenases (ADHs) and aldehyde dehydrogenases (ALDHs) play critical
roles in alcoholism development and alcohol toxicology; however, few studies have focused …

Accumulating evidence has demonstrated that genome-derived noncoding RNAs (ncRNAs)
play important roles in modulating inter-individual variations observed in drug metabolism …

Background: The Ketogenic Diet (KD) promotes metabolic changes and optimizes energy
metabolism. It is unknown if microRNAs (miRs) are influenced by KD in obese subjects. The …

Abstract N, N-Dimethylformamide (DMF) is a universal organic solvent which widely used in
various industries, and a considerable amount of DMF is detected in industrial effluents …

Abstract p66Shc, a master regulator of mitochondrial reactive oxygen species (mtROS), is a
crucial mediator of hepatocyte oxidative stress. However, its functional contribution to …