Immunotherapies have emerged as one of the most promising approaches to treat patients
with cancer. Recently, there have been many clinical successes using checkpoint receptor …

The number of approved or investigational late phase viral vector gene therapies (GTx) has
been rapidly growing. The adeno-associated virus vector (AAV) technology continues to be …

Purpose: To evaluate the results of the randomized, double-blind, placebo-controlled phase
II clinical trial of ICT-107 in patients with newly diagnosed glioblastoma. Patients and …

Cancer‐associated fibroblasts (CAFs) are present in many types of tumors and play a pivotal
role in tumor progression and immunosuppression. Fibroblast‐activation protein (FAP) …

The presented protocol for Elispot plate evaluation summarizes how to implement the
recommendations developed following the establishment of a large-scale international …

The affinity distribution of the antigen-specific memory B cell (Bmem) repertoire in the body
is a critical variable that defines an individual's ability to rapidly generate high-affinity …

Background Accurate quantitation of immune markers is crucial for ensuring reliable
assessment of vaccine efficacy against infectious diseases. This study was designed to …

Purpose Preclinical tumor models show that chemotherapy has immune modulatory
properties which can be exploited in the context of immunotherapy. The purpose of this …

Background The colorectal cancer antigen GUCY2C exhibits unique split tolerance, evoking
antigen-specific CD8+, but not CD4+, T-cell responses that deliver anti-tumor immunity …

Background and Aims Photochemical internalization (PCI) is a technology for inducing
release of endocytosed antigens into the cell cytosol via a light-induced process. Preclinical …