Current progress in the development of hepatitis B virus capsid assembly modulators: chemical structure, mode-of-action and efficacy
H Kim, C Ko, JY Lee, M Kim - Molecules, 2021 - mdpi.com
Hepatitis B virus (HBV) is a major causative agent of human hepatitis. Its viral genome
comprises partially double-stranded DNA, which is complexed with viral polymerase within …
comprises partially double-stranded DNA, which is complexed with viral polymerase within …
Medicinal chemistry strategies in the discovery and optimization of HBV core protein allosteric modulators (2018–2022 update)
X Shao, S Xu, X Wan, Y Zhou, S Wang, S Wu, Y Li… - Chinese Chemical …, 2023 - Elsevier
Despite the improving coverage of preventative vaccines, hepatitis B remains a severe
global public health problem, with more than 250 million patients living with hepatitis B virus …
global public health problem, with more than 250 million patients living with hepatitis B virus …
[HTML][HTML] Synthesis, biological evaluation, molecular docking and in silico ADMET screening studies of novel isoxazoline derivatives from acridone
A series of new acridone derivatives from isoxazoline (2a-l) were synthesized via 1, 3-
dipolar cycloaddition reaction between a variety of aryl nitrile oxides and N-allyl acridones …
dipolar cycloaddition reaction between a variety of aryl nitrile oxides and N-allyl acridones …
Discovery of benzimidazole substituted 1, 2, 4-oxadiazole compounds as novel anti-HBV agents with TLR8-agonistic activities
J Qiu, Y Zou, S Li, L Yang, Z Qiu, F Kong… - European Journal of …, 2022 - Elsevier
Hepatitis B virus (HBV) infection is a public health threat worldwide and characterized by a
dysfunctional immune response. In the present work, a new series of benzimidazole …
dysfunctional immune response. In the present work, a new series of benzimidazole …
Discovery of new small molecule hits as Hepatitis B virus capsid assembly modulators: structure and pharmacophore-based approaches
Hepatitis B virus (HBV) capsid assembly modulators (CpAMs) have shown promise as
potent anti-HBV agents in both preclinical and clinical studies. Herein, we report our efforts …
potent anti-HBV agents in both preclinical and clinical studies. Herein, we report our efforts …
Design, synthesis and biological evaluation of novel dihydrobenzodioxine derivatives as HBV capsid protein inhibitors
L Liu, M Wang, C Li, X Han, Y Xie, K Feng, L Zhang… - Bioorganic …, 2022 - Elsevier
Capsid assembly modulators (CAMs) have recently been revealed to be effective in blocking
HBV replication. HBV capsid protein inhibitors reduce and ultimately eliminate HBV by …
HBV replication. HBV capsid protein inhibitors reduce and ultimately eliminate HBV by …
Targeting the virus capsid as a tool to fight RNA viruses
L Hozáková, B Vokatá, T Ruml, P Ulbrich - Viruses, 2022 - mdpi.com
Several strategies have been developed to fight viral infections, not only in humans but also
in animals and plants. Some of them are based on the development of efficient vaccines, to …
in animals and plants. Some of them are based on the development of efficient vaccines, to …
Exploration of 1-(indolin-1-yl)-2-(thiazol-2-yl) ethan-1-one derivatives as novel anti-HBV agent with potential TLR7-agonistic effect
S Li, L Yang, Q Xu, X Li, J Zhao, Z Tan, X Gu… - European Journal of …, 2024 - Elsevier
Hepatitis B virus (HBV) infection, as a serious global public health issue, is closely related to
the immune dysfunction. Herein, thirty-seven 1-(indolin-1-yl)-2-(thiazol-4-yl) ethan-1-one …
the immune dysfunction. Herein, thirty-seven 1-(indolin-1-yl)-2-(thiazol-4-yl) ethan-1-one …
Design, synthesis, and fungicidal activity of novel N‐substituted piperazine‐containing phenylpyridines against cucumber downy mildew
Y Xu, H Wang, X Du - Pest Management Science, 2022 - Wiley Online Library
BACKGROUND Cucumber downy mildew (CDM) is a severe plant disease and affects the
yield of cucumber production worldwide. As the resistance toward conventional fungicides is …
yield of cucumber production worldwide. As the resistance toward conventional fungicides is …
Design, synthesis, and biological evaluation of novel sulfamoylbenzamide derivatives as HBV capsid assembly modulators
S Wang, Y Ren, Q Li, Y Wang, X Jiang, S Xu… - Bioorganic …, 2022 - Elsevier
Capsid assembly modulators (CAMs) represent a novel class of antiviral agents targeting
hepatitis B virus (HBV) capsid to disrupt the assembly process. NVR 3-778 is the first CAM to …
hepatitis B virus (HBV) capsid to disrupt the assembly process. NVR 3-778 is the first CAM to …