Hyperpolarized Xenon-129 Chemical Exchange Saturation Transfer (HyperCEST) Molecular Imaging: Achievements and Future Challenges

V Batarchuk, Y Shepelytskyi, V Grynko… - International Journal of …, 2024 - mdpi.com
Molecular magnetic resonance imaging (MRI) is an emerging field that is set to revolutionize
our perspective of disease diagnosis, treatment efficacy monitoring, and precision medicine …

Cyclodextrin-Based Contrast Agents for Medical Imaging

Y Shepelytskyi, CJ Newman, V Grynko, LE Seveney… - Molecules, 2020 - mdpi.com
Cyclodextrins (CDs) are naturally occurring cyclic oligosaccharides consisting of multiple
glucose subunits. CDs are widely used in host–guest chemistry and biochemistry due to …

R3-Noria-Methanesulfonate: A Molecular Cage with Superior Hyperpolarized Xenon-129 MRI Contrast

Y Shepelytskyi, V Grynko, V Batarchuk… - ACS …, 2023 - ACS Publications
Hyperpolarized (HP) xenon-129 (129Xe) magnetic resonance imaging (MRI) has the
potential to be used as a molecular imaging modality. For this purpose, numerous …

Cucurbit [6] uril Hyperpolarized Chemical Exchange Saturation Transfer Pulse Sequence Parameter Optimization and Detectability Limit Assessment at 3.0 T

V Grynko, Y Shepelytskyi, V Batarchuk… - …, 2023 - Wiley Online Library
Molecular imaging is the future of personalized medicine; however, it requires effective
contrast agents. Hyperpolarized chemical exchange saturation transfer (HyperCEST) can …

Rotaxane Probes for the Detection of Hydrogen Peroxide by 129Xe HyperCEST NMR Spectroscopy

SH Klass, AE Truxal, TA Fiala, J Kelly… - Angewandte Chemie …, 2019 - Wiley Online Library
The development of sensitive and chemically selective MRI contrast agents is imperative for
the early detection and diagnosis of many diseases. Conventional responsive contrast …

Synthesis of cryptophane-B: Crystal structure and study of its complex with xenon

T Brotin, E Jeanneau, P Berthault… - The Journal of …, 2018 - ACS Publications
Whereas the synthesis of the anti-cryptophane-A (1) derivative has been known for nearly
40 years, the preparation of its diastereomer (cryptophane-B according to Collet's …

Decacationic Pillar[5]arene: A New Scaffold for the Development of 129Xe MRI Imaging Agents

PUAI Fernando, Y Shepelytskyi, PT Cesana… - ACS …, 2020 - ACS Publications
A decacationic water-soluble pillar [5] arene possessing a nonsolvated hydrophobic core
has been designed and synthesized. This supramolecular host is capable of binding xenon …

Monomeric Cryptophane with Record-High Xe Affinity Gives Insights into Aggregation-Dependent Sensing

SD Zemerov, Y Lin, IJ Dmochowski - Analytical chemistry, 2020 - ACS Publications
Cryptophane host molecules provide ultrasensitive contrast agents for 129Xe NMR/MRI. To
investigate key features of cryptophane–Xe sensing behavior, we designed a novel water …

129Xe NMR-Protein Sensor Reveals Cellular Ribose Concentration

SD Zemerov, BW Roose, KL Farenhem… - Analytical …, 2020 - ACS Publications
Dysregulation of cellular ribose uptake can be indicative of metabolic abnormalities or
tumorigenesis. However, analytical methods are currently limited for quantifying ribose …

A polycationic pillar [5] arene for the binding and removal of organic toxicants from aqueous media

A Fernando, TL Mako, AM Levenson… - Supramolecular …, 2019 - Taylor & Francis
The ability to bind and detect analytes with high levels of selectivity, sensitivity and broad
applicability for a variety of analytes is an essential goal, with applications in public health …