Hyperpolarized Xenon-129 Chemical Exchange Saturation Transfer (HyperCEST) Molecular Imaging: Achievements and Future Challenges
V Batarchuk, Y Shepelytskyi, V Grynko… - International Journal of …, 2024 - mdpi.com
Molecular magnetic resonance imaging (MRI) is an emerging field that is set to revolutionize
our perspective of disease diagnosis, treatment efficacy monitoring, and precision medicine …
our perspective of disease diagnosis, treatment efficacy monitoring, and precision medicine …
Cyclodextrin-Based Contrast Agents for Medical Imaging
Y Shepelytskyi, CJ Newman, V Grynko, LE Seveney… - Molecules, 2020 - mdpi.com
Cyclodextrins (CDs) are naturally occurring cyclic oligosaccharides consisting of multiple
glucose subunits. CDs are widely used in host–guest chemistry and biochemistry due to …
glucose subunits. CDs are widely used in host–guest chemistry and biochemistry due to …
R3-Noria-Methanesulfonate: A Molecular Cage with Superior Hyperpolarized Xenon-129 MRI Contrast
Y Shepelytskyi, V Grynko, V Batarchuk… - ACS …, 2023 - ACS Publications
Hyperpolarized (HP) xenon-129 (129Xe) magnetic resonance imaging (MRI) has the
potential to be used as a molecular imaging modality. For this purpose, numerous …
potential to be used as a molecular imaging modality. For this purpose, numerous …
Cucurbit [6] uril Hyperpolarized Chemical Exchange Saturation Transfer Pulse Sequence Parameter Optimization and Detectability Limit Assessment at 3.0 T
V Grynko, Y Shepelytskyi, V Batarchuk… - …, 2023 - Wiley Online Library
Molecular imaging is the future of personalized medicine; however, it requires effective
contrast agents. Hyperpolarized chemical exchange saturation transfer (HyperCEST) can …
contrast agents. Hyperpolarized chemical exchange saturation transfer (HyperCEST) can …
Rotaxane Probes for the Detection of Hydrogen Peroxide by 129Xe HyperCEST NMR Spectroscopy
The development of sensitive and chemically selective MRI contrast agents is imperative for
the early detection and diagnosis of many diseases. Conventional responsive contrast …
the early detection and diagnosis of many diseases. Conventional responsive contrast …
Synthesis of cryptophane-B: Crystal structure and study of its complex with xenon
T Brotin, E Jeanneau, P Berthault… - The Journal of …, 2018 - ACS Publications
Whereas the synthesis of the anti-cryptophane-A (1) derivative has been known for nearly
40 years, the preparation of its diastereomer (cryptophane-B according to Collet's …
40 years, the preparation of its diastereomer (cryptophane-B according to Collet's …
Decacationic Pillar[5]arene: A New Scaffold for the Development of 129Xe MRI Imaging Agents
A decacationic water-soluble pillar [5] arene possessing a nonsolvated hydrophobic core
has been designed and synthesized. This supramolecular host is capable of binding xenon …
has been designed and synthesized. This supramolecular host is capable of binding xenon …
Monomeric Cryptophane with Record-High Xe Affinity Gives Insights into Aggregation-Dependent Sensing
SD Zemerov, Y Lin, IJ Dmochowski - Analytical chemistry, 2020 - ACS Publications
Cryptophane host molecules provide ultrasensitive contrast agents for 129Xe NMR/MRI. To
investigate key features of cryptophane–Xe sensing behavior, we designed a novel water …
investigate key features of cryptophane–Xe sensing behavior, we designed a novel water …
129Xe NMR-Protein Sensor Reveals Cellular Ribose Concentration
SD Zemerov, BW Roose, KL Farenhem… - Analytical …, 2020 - ACS Publications
Dysregulation of cellular ribose uptake can be indicative of metabolic abnormalities or
tumorigenesis. However, analytical methods are currently limited for quantifying ribose …
tumorigenesis. However, analytical methods are currently limited for quantifying ribose …
A polycationic pillar [5] arene for the binding and removal of organic toxicants from aqueous media
A Fernando, TL Mako, AM Levenson… - Supramolecular …, 2019 - Taylor & Francis
The ability to bind and detect analytes with high levels of selectivity, sensitivity and broad
applicability for a variety of analytes is an essential goal, with applications in public health …
applicability for a variety of analytes is an essential goal, with applications in public health …