Unveiling anti-diabetic potential of new thiazole-sulfonamide derivatives: Design, synthesis, in vitro bio-evaluation targeting DPP-4, α-glucosidase, and α-amylase with …
Diabetes mellitus type 2 (T2DM) can be managed by targeting dipeptidyl peptidase-4 (DPP-
4), an enzyme that breaks down and deactivates peptides such as GIP and GLP-1. In this …
4), an enzyme that breaks down and deactivates peptides such as GIP and GLP-1. In this …
Plant-Derived Proteins and Peptides as Potential Immunomodulators
I Szerszunowicz, S Kozicki - Molecules, 2023 - mdpi.com
The immune response of humans may be modulated by certain biopeptides. The present
study aimed to determine the immunomodulatory potential of plant-derived food proteins …
study aimed to determine the immunomodulatory potential of plant-derived food proteins …
[HTML][HTML] Angular-Substituted [1, 4] Thiazino [3, 4-a] Isoquinolines: Biological Evaluation and In Silico Studies on DPP-IV Inhibition
Recent studies have discovered that aryl-substituted pyrido [2, 1-a] isoquinolines have the
potential to be highly active DPP IV inhibitors. In previous studies, we reported a novel …
potential to be highly active DPP IV inhibitors. In previous studies, we reported a novel …
Prediction of Protein-Drug Interactions, Pharmacophore Modeling, and Toxicokinetics of Novel Leads for Type 2 Diabetes Treatment
A Mehra, A Mittal, PK Vishwakarma - Current Drug Metabolism, 2024 - ingentaconnect.com
Background: Small heterocyclic compounds have been crucial in pioneering advances in
type 2 diabetes treatment. There has been a dramatic increase in the pharmacological …
type 2 diabetes treatment. There has been a dramatic increase in the pharmacological …
Identification of small-molecule glucokinase activator for type-2-diabetes treatment: a structure-based virtual screening approach
ABSTRACT Glucokinase (GK, EC 2.7. 1.2) is a crucial enzyme that catalyses the conversion
of glucose to glucose-6-phosphate. It is used to treat type-2 diabetes (T2D), a serious …
of glucose to glucose-6-phosphate. It is used to treat type-2 diabetes (T2D), a serious …
Zr-MOF-N= CH-C6H4-OSO3H catalyst for the construction of new substituted 4-aminocoumarin analogs
MG Chegini, M Mokhtary… - Iranian Journal of Catalysis, 2024 - oiccpress.com
In this study, the preparation of a new functionalized acidic metal-organic framework
nanocatalyst formulated as Zr-MOF-N= CH-C6H4-SO3H has been reported. After …
nanocatalyst formulated as Zr-MOF-N= CH-C6H4-SO3H has been reported. After …
Insilco Evaluation of Psoralea corylifolia for Novel Anti-Tubercular Compounds: Virtual Screening, Molecular Docking, and Dynamics Simulation Analysis
J Madhusudhanan, S Usharani - Current Trends in Biotechnology and …, 2024 - abap.co.in
Mycobacterium tuberculosis, the causative agent of tuberculosis (TB), remains a significant
global health concern, causing millions of infections and deaths each year. The emergence …
global health concern, causing millions of infections and deaths each year. The emergence …
Novel Coumarin-Furo [2, 3-d] Pyrimidinone Hybrid Derivatives: Design, Anticancer Evaluation and Molecular Docking
Y Jin, S He, F Wu, C Luo, J Ma, Y Hu - Anticancer Evaluation and … - papers.ssrn.com
A series of coumarin-furo [2, 3-d] pyrimidinone hybrid derivatives were synthesized and
evaluated potential cytotoxicity effects against hepatic carcinoma (HepG2) and cervical …
evaluated potential cytotoxicity effects against hepatic carcinoma (HepG2) and cervical …