Protozoan parasites have developed elaborate motility systems that facilitate infection and
dissemination. For example, amoebae use actin-rich membrane extensions called …

The mosquito midgut stages of malaria parasites are crucial for establishing an infection in
the insect vector and to thus ensure further spread of the pathogen. Parasite development in …

Background Rodent malaria parasites (RMP) are used extensively as models of human
malaria. Draft RMP genomes have been published for Plasmodium yoelii, P. berghei ANKA …

Malaria-causing parasites of the Plasmodium genus undergo multiple developmental
phases in the human and the mosquito hosts, regulated by various post-translational …

Members of Apicomplexa are defined by apical cytoskeletal structures and secretory
organelles, tailored for motility, invasion and egress. Gliding is powered by actomyosin …

A family of apicomplexa-specific proteins containing AP2 DNA-binding domains (ApiAP2s)
was identified in malaria parasites. This family includes sequence-specific transcription …

Many critical events in the Plasmodium life cycle rely on the controlled release of Ca2+ from
intracellular stores to activate stage-specific Ca2+-dependent protein kinases. Using the …

Kinetochores are multiprotein assemblies directing mitotic spindle attachment and
chromosome segregation. In apicomplexan parasites, most known kinetochore components …

Preventing human-to-mosquito transmission of malaria parasites provides possible
solutions to interrupt the malaria parasite life cycle for malaria elimination. The development …

Calcium signalling coordinates motility, cell invasion, and egress by apicomplexan
parasites, yet the key mediators that transduce these signals remain largely unknown. One …