Abstract Neurofibromatosis type 1 (NF1) is an autosomal dominant tumour predisposition
syndrome that is caused through loss of function mutations of a tumour suppressor gene …

The NF1 gene encodes neurofibromin, which is one of the primary negative regulatory
factors of the Ras protein. Neurofibromin stimulates the GTPase activity of Ras to convert it …

A recent genome-wide association meta-analysis for Alzheimer's disease (AD) identified 19
risk loci (in addition to APOE) in which the functional genes are unknown. Using Drosophila …

Abstract Neurofibromatosis type 1 (NF1) is a common neurodevelopmental disorder in
which affected individuals are prone to learning, attention and behavioral problems …

During development, neurons achieve a stereotyped neuron type-specific morphology,
which relies on dynamic support by microtubules (MTs). An important player is the augmin …

Neurofibromatosis type 1 (NF1) gene mutations or alterations occur within neurofibromatosis
type 1 as well as in many different malignant tumours on the somatic level. In glioblastoma …

Autism spectrum disorder (ASD) is a neurodevelopmental condition in which the
mechanisms underlying its core symptomatology are largely unknown. Studying animal …

Neurofibromatosis type 1 is a monogenetic disorder that predisposes individuals to tumor
formation and cognitive and behavioral symptoms. The neuronal circuitry and …

Mutations that activate the RAS oncoproteins are common in cancer. However, aberrant
upregulation of RAS activity often occurs in the absence of activating mutations in the RAS …

Neurofibromatosis type 1 (NF1), a genetic disease that affects 1 in 3,000, is caused by loss
of a large evolutionary conserved protein that serves as a GTPase Activating Protein (GAP) …