Stem cell niches are specialized microenvironments that promote the maintenance of stem
cells and regulate their function. Recent advances have improved our understanding of the …

Evidence of the diversity and multi-layered organization of the hematopoietic system is
leading to new insights that may inform ex vivo production of blood cells. Interestingly, not all …

Tissue-specific stem cells persist for a lifetime and can differentiate to maintain homeostasis
or transform to initiate cancer. Despite their importance, there are no described quality …

Macrophages are essential for appendage regeneration after amputation in regenerative
species. The molecular mechanisms through which macrophages orchestrate blastema …

Inflammation exerts multiple effects on the early hematopoietic compartment. Best studied is
the role of proinflammatory cytokines in activating adult hematopoietic stem and progenitor …

Cancer immunoediting is a dynamic process of crosstalk between tumor cells and the
immune system. Herein, we explore the fast zebrafish xenograft model to investigate the …

Cell motility is required for diverse processes during immunity and inflammation. Classically,
leukocyte motility is defined as an amoeboid type of migration, however some leukocytes …

Macrophages, named for their phagocytic ability, participate in homeostasis, tissue
regeneration and inflammatory responses. Bone and adjacent marrow contain multiple …

The mononuclear phagocytic system consists of many cells, in particular macrophages,
scattered throughout the body. However, there is increasing evidence for the heterogeneity …

Macrophages are phagocytic cells from the innate immune system, which forms the first line
of host defense against invading pathogens. These highly dynamic immune cells can adopt …