Pathogenetic mechanisms and treatment targets in cerebral malaria
Malaria, the most prevalent mosquito-borne infectious disease worldwide, has accompanied
humanity for millennia and remains an important public health issue despite advances in its …
humanity for millennia and remains an important public health issue despite advances in its …
Pathogenicity and virulence of malaria: Sticky problems and tricky solutions
IS Walker, SJ Rogerson - Virulence, 2023 - Taylor & Francis
Infections with Plasmodium falciparum and Plasmodium vivax cause over 600,000 deaths
each year, concentrated in Africa and in young children, but much of the world's population …
each year, concentrated in Africa and in young children, but much of the world's population …
CD36—A host receptor necessary for malaria parasites to establish and maintain infection
A Bachmann, NG Metwally, J Allweier, J Cronshagen… - Microorganisms, 2022 - mdpi.com
Plasmodium falciparum-infected erythrocytes (Pf IEs) present P. falciparum erythrocyte
membrane protein 1 proteins (Pf EMP1s) on the cell surface, via which they cytoadhere to …
membrane protein 1 proteins (Pf EMP1s) on the cell surface, via which they cytoadhere to …
The Kelch13 compartment contains highly divergent vesicle trafficking proteins in malaria parasites
S Schmidt, JS Wichers-Misterek, HM Behrens… - Plos …, 2023 - journals.plos.org
Single amino acid changes in the parasite protein Kelch13 (K13) result in reduced
susceptibility of P. falciparum parasites to artemisinin and its derivatives (ART). Recent work …
susceptibility of P. falciparum parasites to artemisinin and its derivatives (ART). Recent work …
A novel computational pipeline for var gene expression augments the discovery of changes in the Plasmodium falciparum transcriptome during transition from in vivo …
C Andradi-Brown, JS Wichers-Misterek, H von Thien… - Elife, 2024 - elifesciences.org
The pathogenesis of severe Plasmodium falciparum malaria involves cytoadhesive
microvascular sequestration of infected erythrocytes, mediated by P. falciparum erythrocyte …
microvascular sequestration of infected erythrocytes, mediated by P. falciparum erythrocyte …
Antibody to Plasmodium falciparum Variant Surface Antigens, var Gene Transcription, and ABO Blood Group in Children With Severe or Uncomplicated Malaria
Background Antibodies to variant surface antigens (VSAs) such as Plasmodium falciparum
erythrocyte membrane protein 1 (PfEMP1) may vary with malaria severity. The influence of …
erythrocyte membrane protein 1 (PfEMP1) may vary with malaria severity. The influence of …
The exception that proves the rule: Virulence gene expression at the onset of Plasmodium falciparum blood stage infections
JS Wichers-Misterek, R Krumkamp, J Held… - Plos …, 2023 - journals.plos.org
Controlled human malaria infections (CHMI) are a valuable tool to study parasite gene
expression in vivo under defined conditions. In previous studies, virulence gene expression …
expression in vivo under defined conditions. In previous studies, virulence gene expression …
[HTML][HTML] Elevated plasma soluble ST2 levels are associated with neuronal injury and neurocognitive impairment in children with cerebral malaria
EM Fernander, P Adogamhe, D Datta… - Pathogens and …, 2022 - ncbi.nlm.nih.gov
Background: Murine experimental cerebral malaria studies suggest both protective and
deleterious central nervous system effects from alterations in the interleukin-33 (IL-33)/ST2 …
deleterious central nervous system effects from alterations in the interleukin-33 (IL-33)/ST2 …
Altered Cytokine Response of Human Brain Endothelial Cells after Stimulation with Malaria Patient Plasma
M Raacke, A Kerr, M Dörpinghaus, J Brehmer, Y Wu… - Cells, 2021 - mdpi.com
Infections with the deadliest malaria parasite, Plasmodium falciparum, are accompanied by
a strong immunological response of the human host. To date, more than 30 cytokines have …
a strong immunological response of the human host. To date, more than 30 cytokines have …
Transcriptome Analysis of Plasmodium falciparum Isolates From Benin Reveals Specific Gene Expression Associated With Cerebral Malaria
E Guillochon, J Fraering, V Joste… - The Journal of …, 2022 - academic.oup.com
Cerebral malaria (CM) is the severest form of Plasmodium falciparum infection. Children
under 5 years old are those most vulnerable to CM, and they consequently have the highest …
under 5 years old are those most vulnerable to CM, and they consequently have the highest …