Evaluation of integrative clustering methods for the analysis of multi-omics data

C Chauvel, A Novoloaca, P Veyre… - Briefings in …, 2020 - academic.oup.com
Recent advances in sequencing, mass spectrometry and cytometry technologies have
enabled researchers to collect large-scale omics data from the same set of biological …

Computational techniques and tools for omics data analysis: state-of-the-art, challenges, and future directions

P Kaur, A Singh, I Chana - Archives of Computational Methods in …, 2021 - Springer
The heterogeneous and high-dimensional nature of omics data presents various challenges
in gaining insights while analysis. In the era of big data, omics data is available as genome …

Discovering microRNA-regulatory modules in multi-dimensional cancer genomic data: a survey of computational methods

CJ Walsh, P Hu, J Batt, CCD Santos - Cancer informatics, 2016 - journals.sagepub.com
MicroRNAs (miRs) are small single-stranded noncoding RNA that function in RNA silencing
and post-transcriptional regulation of gene expression. An increasing number of studies …

Prediction with dimension reduction of multiple molecular data sources for patient survival

A Kaplan, EF Lock - Cancer informatics, 2017 - journals.sagepub.com
Predictive modeling from high-dimensional genomic data is often preceded by a dimension
reduction step, such as principal component analysis (PCA). However, the application of …

Integrative analysis reveals disrupted pathways regulated by microRNAs in cancer

G Wilk, R Braun - Nucleic Acids Research, 2018 - academic.oup.com
MicroRNAs (miRNAs) are small endogenous regulatory molecules that modulate gene
expression post-transcriptionally. Although differential expression of miRNAs have been …

Identifying cancer patient subgroups by finding co-modules from the driver mutation profiles and downstream gene expression profiles

J Song, W Peng, F Wang - IEEE/ACM Transactions on …, 2021 - ieeexplore.ieee.org
Nowadays, the heterogeneous characteristics of cancer patients throw a big challenge to
precision medicine and targeted therapy. Identifying cancer subtypes shed new light on …

[HTML][HTML] How does cloud computing improve cancer information management? A systematic review

L Erfannia, J Alipour - Informatics in Medicine Unlocked, 2022 - Elsevier
Objective There has been exponential growth in the volume, variety, and velocity of cancer
data. Cloud computing (CC) plays a pivotal role in the managing of cancer big data by …

[HTML][HTML] An integrated transcriptomics and metabolomics study of the immune response of newly hatched chicks to the cytosine-phosphate-guanine oligonucleotide …

DA Ouattara, L Remolue, J Becker, M Perret… - Poultry science, 2020 - Elsevier
The immunological immaturity of the innate immune system during the first-week post-hatch
enables pathogens to infect chickens, leading to the death of the animals. Current …

Integrating open data on cancer in support to tumor growth analysis

F Jeanquartier, C Jean-Quartier, T Schreck… - … Technology in Bio-and …, 2016 - Springer
The general disease group of malignant neoplasms depicts one of the leading and
increasing causes for death. The underlying complexity of cancer demands for abstractions …

Integrative Classification Using Structural Equation Modeling of Homeostasis

HB Fang, H Huang, A Yuan, R Fan, MT Tan - Statistics in Biosciences, 2024 - Springer
We consider binary classification in the high-dimensional setting, where the number of
features is huge, and the number of observations is limited. We focus on the setting where …