[HTML][HTML] Astrocyte heterogeneity: impact to brain aging and disease

I Matias, J Morgado, FCA Gomes - Frontiers in aging neuroscience, 2019 - frontiersin.org
Astrocytes, one of the largest glial cell population in the central nervous system (CNS), play
a key function in several events of brain development and function, such as synapse …

Role and mechanisms of cytokines in the secondary brain injury after intracerebral hemorrhage

H Zhu, Z Wang, J Yu, X Yang, F He, Z Liu, F Che… - Progress in …, 2019 - Elsevier
Intracerebral hemorrhage (ICH) is a common and severe cerebrovascular disease that has
high mortality. Few survivors achieve self-care. Currently, patients receive only symptomatic …

[HTML][HTML] Neuroprotective effect of quercetin against the detrimental effects of LPS in the adult mouse brain

A Khan, T Ali, SU Rehman, MS Khan, SI Alam… - Frontiers in …, 2018 - frontiersin.org
Chronic neuroinflammation is responsible for multiple neurodegenerative diseases, such as
Alzheimer's disease, Parkinson's disease, and Huntington's disease. Lipopolysaccharide …

Loss of lamin‐B1 and defective nuclear morphology are hallmarks of astrocyte senescence in vitro and in the aging human hippocampus

I Matias, LP Diniz, IV Damico, APB Araujo… - Aging cell, 2022 - Wiley Online Library
The increase in senescent cells in tissues, including the brain, is a general feature of normal
aging and age‐related pathologies. Senescent cells exhibit a specific phenotype, which …

[HTML][HTML] Acetylcholinesterase inhibitors in the treatment of neurodegenerative diseases and the role of acetylcholinesterase in their pathogenesis

ŁJ Walczak-Nowicka, M Herbet - International journal of molecular …, 2021 - mdpi.com
Acetylcholinesterase (AChE) plays an important role in the pathogenesis of
neurodegenerative diseases by influencing the inflammatory response, apoptosis, oxidative …

Flavonoids as therapeutic agents in Alzheimer's and Parkinson's diseases: a systematic review of preclinical evidences

RB de Andrade Teles, TC Diniz… - Oxidative medicine …, 2018 - Wiley Online Library
Alzheimer's and Parkinson's diseases are considered the most common neurodegenerative
disorders, representing a major focus of neuroscience research to understanding the …

[HTML][HTML] The benefits of hesperidin in central nervous system disorders, based on the neuroprotective effect

X Li, W Huang, R Tan, C Xu, X Chen, S Li, Y Liu… - Biomedicine & …, 2023 - Elsevier
Disorders of central nervous system (CNS) disorders are considered serious health issues.
The most common CNS diseases include neurodegenerative diseases, mental disorders …

[HTML][HTML] Plant-derived antioxidants protect the nervous system from aging by inhibiting oxidative stress

X Cui, Q Lin, Y Liang - Frontiers in aging neuroscience, 2020 - frontiersin.org
Alzheimer's disease (AD) has become a major disease contributing to human death and is
thought to be closely related to the aging process. The rich antioxidant substances in plants …

Astrocytes and the TGF-β1 pathway in the healthy and diseased brain: a double-edged sword

LP Diniz, I Matias, M Siqueira, J Stipursky… - Molecular …, 2019 - Springer
Transforming growth factor betas (TGF-βs) are known as multifunctional growth factors that
participate in the regulation of key events of development, disease, and tissue repair. In the …

[HTML][HTML] Contribution of Müller cells in the diabetic retinopathy development: Focus on oxidative stress and inflammation

R Carpi-Santos, RA de Melo Reis, FCA Gomes… - Antioxidants, 2022 - mdpi.com
Diabetic retinopathy is a neurovascular complication of diabetes and the main cause of
vision loss in adults. Glial cells have a key role in maintenance of central nervous system …