It has long been hypothesized that conditioning mechanisms play major roles in addiction.
Specifically, the associations between rewarding properties of drugs of abuse and the drug …

The brain regions and neural processes that underlie addiction overlap extensively with
those that support cognitive functions, including learning, memory, and reasoning. Drug …

J. Neurochem.(2010) 114, 675–684. Abstract Different mechanisms have been suggested
for cocaine toxicity including an increase in oxidative stress but the association between …

Drug addiction is a chronic brain disorder, characterized by the loss of the ability to control
drug consumption. The neurobiology of addiction is traditionally thought to involve the …

Adolescence is a time of exploration of the self, and this exploration may involve the use of
alcohol and drugs. Sadly, for some, adolescence also marks the first signs of a psychosis …

It is increasingly recognized that studying drug taking in laboratory animals does not equate
to studying genuine addiction, characterized by loss of control over drug use. This has …

Relapse, a major problem in the treatment of cocaine addiction, is proposed to result in part
from neuroadaptations in the hippocampus. We examined how a mediator of hippocampal …

Different mechanisms have been suggested for cocaine neurotoxicity, including oxidative
stress alterations. Nuclear factor kappa B (NF-κB), considered a sensor of oxidative stress …

The number of individuals affected by psychostimulant use disorder (PSUD) has increased
rapidly over the last few decades resulting in economic, emotional, and physical burdens on …

The effects of drugs of abuse, such as cocaine, on learning and memory processes are
thought to contribute to drug craving and relapse susceptibility. Using an Escalating (Esc) or …