Affective and substance-use disorders are associated with overweight and obesity-related
complications, which are often due to the overconsumption of palatable food. Both high-fat …

Precipitous declines in cognitive function can occur in older individuals following a variety of
peripheral immune insults, such as surgery, infection, injury, and unhealthy diet. Aging is …

Chronic stress is known to perturb serotonergic regulation in the brain, leading to mood,
learning and memory impairments and increasing the risk of developing mood disorders …

Growing evidence suggests that a high fat diet (HFD) induces oxidative stress on the central
nervous system (CNS), which predisposes to mood disorders and neuroinflammation. In this …

Maternal high-fat diets (HFD) can generate inflammation in the offspring's amygdala, which
can lead to anxiety-like behaviors. Conversely, lipopolysaccharide (LPS) tolerance can …

Nutrient composition in obesogenic diets may influence the severity of disorders associated
with obesity such as insulin-resistance and chronic inflammation. Here we hypothesized that …

Background Little is known about how the obesogenic environment influences emotional
states associated with glial responses and neuronal function. Here, we investigated glial …

Obesity and mood disorders are two of the most serious health issues of modern times.
These health conditions are often linked, with obesity acting both as a cause and …

Factors linked to modern lifestyles, such as physical inactivity, Western diet, and poor sleep
quality have been identified as key contributors to the positive energy balance (PEB). PEB …

Obesity is linked to metabolic, hormonal and biochemical alterations, and is also a risk factor
for behavioral disorders. Evidence suggests that these disorders may be related to the …