Parvalbumin role in epilepsy and psychiatric comorbidities: from mechanism to intervention
Parvalbumin is a calcium-binding protein present in inhibitory interneurons that play an
essential role in regulating many physiological processes, such as intracellular signaling …
essential role in regulating many physiological processes, such as intracellular signaling …
[HTML][HTML] Neural circuit changes in neurological disorders: evidence from in vivo two-photon imaging
Neural circuits, such as synaptic plasticity and neural activity, are critical components of
healthy brain function. The consequent dynamic remodeling of neural circuits is an ongoing …
healthy brain function. The consequent dynamic remodeling of neural circuits is an ongoing …
Developmentally regulated impairment of parvalbumin interneuron synaptic transmission in an experimental model of Dravet syndrome
Dravet syndrome is a neurodevelopmental disorder characterized by epilepsy, intellectual
disability, and sudden death due to pathogenic variants in SCN1A with loss of function of the …
disability, and sudden death due to pathogenic variants in SCN1A with loss of function of the …
VIP interneuron impairment promotes in vivo circuit dysfunction and autism-related behaviors in Dravet syndrome
Dravet syndrome (DS) is a severe neurodevelopmental disorder caused by loss-of-function
variants in SCN1A, which encodes the voltage-gated sodium channel subunit Nav1. 1. We …
variants in SCN1A, which encodes the voltage-gated sodium channel subunit Nav1. 1. We …
Transfer of SCN1A to the brain of adolescent mouse model of Dravet syndrome improves epileptic, motor, and behavioral manifestations
L Mora-Jimenez, M Valencia… - … Therapy-Nucleic Acids, 2021 - cell.com
Dravet syndrome is a genetic encephalopathy characterized by severe epilepsy combined
with motor, cognitive, and behavioral abnormalities. Current antiepileptic drugs achieve only …
with motor, cognitive, and behavioral abnormalities. Current antiepileptic drugs achieve only …
[HTML][HTML] Developmental alterations in firing properties of hippocampal CA1 inhibitory and excitatory neurons in a mouse model of Dravet syndrome
Dravet syndrome (Dravet) is a rare, severe childhood-onset epilepsy, caused by
heterozygous de novo mutations in the SCN1A gene, encoding for the alpha subunit of the …
heterozygous de novo mutations in the SCN1A gene, encoding for the alpha subunit of the …
Circuit-level theories for sensory dysfunction in autism: convergence across mouse models
Individuals with autism spectrum disorder (ASD) exhibit a diverse range of behavioral
features and genetic backgrounds, but whether different genetic forms of autism involve …
features and genetic backgrounds, but whether different genetic forms of autism involve …
Corticohippocampal circuit dysfunction in a mouse model of Dravet syndrome
Dravet syndrome (DS) is a neurodevelopmental disorder due to pathogenic variants in
SCN1A encoding the Nav1. 1 sodium channel subunit, characterized by treatment-resistant …
SCN1A encoding the Nav1. 1 sodium channel subunit, characterized by treatment-resistant …
Dopamine depletion selectively disrupts interactions between striatal neuron subtypes and LFP oscillations
Dopamine degeneration in Parkinson's disease (PD) dysregulates the striatal neural
network and causes motor deficits. However, it is unclear how altered striatal circuits relate …
network and causes motor deficits. However, it is unclear how altered striatal circuits relate …
Reduced GABAergic neuron excitability, altered synaptic connectivity, and seizures in a KCNT1 gain-of-function mouse model of childhood epilepsy
Summary Gain-of-function (GOF) variants in K+ channels cause severe childhood
epilepsies, but there are no mechanisms to explain how increased K+ currents lead to …
epilepsies, but there are no mechanisms to explain how increased K+ currents lead to …