Current medication for anxiety disorders is suboptimal in terms of efficiency and tolerability,
highlighting the need for improved drug treatments. In this review an overview of drugs …

The validity of widely used rodent behavioural tests of anxiety has been questioned, as they
often fail to produce consistent results across independent replicate studies. In this study, we …

Various tests have been developed to evaluate behavior in animal studies where rodents
are used as animal models. These tests are useful for understanding the pathophysiology of …

Anxiety is a common complaint following acquired traumatic brain injury (TBI). However, the
measurement of dysfunctional anxiety behavioral states following experimental TBI in …

Pain and anxiety are two of the most important concerns in clinical veterinary medicine
because they arise as consequences of multiple factors that can severely affect animal …

Animal models of depression are certainly needed but the question in the title has been
raised owing to the controversies in the interpretation of the readout in a number of tests, to …

A wide variety of human diseases have been modelled in zebrafish, including various types
of cancer, cardiovascular diseases and neurodegenerative diseases like Alzheimer's and …

Fear and anxiety are largely seen as separate entities, a distinction that inspires and shapes
basic and clinical research. Evidence for this distinction has a rich translational base and …

Behavioural anxiety tests in non-human animals are used for anxiolytic drug discovery, and
to investigate the neurobiology of threat avoidance. Over the past decade, several of them …

Animal models are used to study neurobiological mechanisms in mental disorders. Although
there has been significant progress in the understanding of neurobiological underpinnings …