The biological functions of sirtuin 6 (SIRT6; eg, deacetylation, defatty‐acylation, and mono‐
ADP‐ribosylation) play a pivotal role in regulating lifespan and several fundamental …

Sirtuin 6 (SIRT6) has been in the spotlight of aging research because progeroid phenotypes
are associated with SIRT6 deficiency. SIRT6 has multiple molecular functions, including …

Vascular calcification (VC) is regarded as an important pathological change lacking effective
treatment and associated with high mortality. Sirtuin 6 (SIRT6) is a member of the Sirtuin …

Aims Exercise confers protection against cardiovascular ageing, but the mechanisms remain
largely unknown. This study sought to investigate the role of fibronectin type-III domain …

Ischemic stroke is the second leading cause of death worldwide with limited medications
and neuroinflammation was recognized as a critical player in the progression of stroke, but …

As an important NAD+-dependent enzyme, SIRT6 has received significant attention since its
discovery. In view of observations that SIRT6-deficient animals exhibit genomic instability …

Postoperative cognitive dysfunction (POCD) is a severe neurological complication after
anesthesia and surgery. However, there is still a lack of effective clinical pharmacotherapy …

Aims Mitochondrial perturbations are the major culprit of the inflammatory response during
the initial phase of cerebral ischemia. The present study explored the neuroprotective effect …

Maintenance of cerebral blood vessel integrity and regulation of cerebral blood flow ensure
proper brain function. The adult human brain represents only a small portion of the body …

Blood-brain barrier (BBB) function deteriorates during aging, contributing to cognitive
impairment and neurodegeneration. It is unclear what drives BBB leakage in aging and how …