Aging is the greatest risk factor for a multitude of diseases including cardiovascular disease,
neurodegeneration and cancer. Despite decades of research dedicated to understanding …

Among other mechanisms, oxidative stress has been postulated to play an important role in
the rate of ageing. Oxidative damage contributes to the hallmarks of ageing and essential …

Age-related impairment of angiogenesis likely has a critical role in cerebromicrovascular
rarefaction and development of vascular cognitive impairment and dementia (VCID) in the …

Aging is associated with increased oxidative stress in vascular endothelial and smooth
muscle cells, which contribute to the development of a wide range of diseases affecting the …

The reduced form of nicotinamide adenine dinucleotide phosphate (NADPH) protects
against redox stress by providing reducing equivalents to antioxidants such as glutathione …

Age-related alterations in endothelium and the resulting vascular dysfunction critically
contribute to a range of pathological conditions associated with old age. To develop …

Several strategies, including chemotherapy and radiotherapy, have improved therapeutic
outcomes among cancer patients in clinical practice. However, due to their heterogeneity …

Thioredoxin and thioredoxin reductase are evolutionarily conserved antioxidant enzymes
that protect organisms from oxidative stress. These proteins also play roles in redox …

With a rapidly growing elderly human population, the incidence of age-related lung diseases
such as chronic obstructive pulmonary disease (COPD) continues to rise. It is widely …

Background: Glioblastoma (GBM) represents the most aggressive glioma with high invasive
potential. Recent studies proved the involvement of epithelial-mesenchymal transition (EMT) …