Tendinopathy is a multi-faceted pathology characterized by alterations in tendon
microstructure, cellularity and collagen composition. Challenged by the possibility of …

Additive manufacturing technologies have become at the forefront in tissue engineering,
enabling the fabrication of complex tissues with intricate geometries that were not feasible …

Cells sense and respond to a variety of physical cues from their surrounding
microenvironment, and these are interpreted through mechanotransductive processes to …

Tendon is a highly organized tissue that transmits forces between muscle and bone. The
architecture of the extracellular matrix of tendon, predominantly from collagen type I, is …

Surface topographies of cell culture substrates can be used to generate in vitro cell culture
environments similar to the in vivo cell niches. In vivo, the physical properties of the …

Approximately 1% of active individuals participating in sports rupture their anterior cruciate
ligaments (ACL) every year, which is currently reconstructed using tendon autografts. Upon …

Reciprocity between cells and their surrounding extracellular matrix is one of the main
drivers for cellular function and, in turn, matrix maintenance and remodelling. Unravelling …

Cells probe their environment and adapt their shape accordingly via the organization of
focal adhesions and the actin cytoskeleton. In an earlier publication, we described the …

Bone is a complex natural material with a complex hierarchical multiscale organization,
crucial to perform its functions. Ultrastructural analysis of bone is crucial for our …

Background Tendon is a major component of musculoskeletal system connecting the
muscles to the bone. Tendon injuries are very common orthopedics problems leading to …