[HTML][HTML] The tendon microenvironment: Engineered in vitro models to study cellular crosstalk
M Gomez-Florit, CJ Labrador-Rached… - Advanced Drug Delivery …, 2022 - Elsevier
Tendinopathy is a multi-faceted pathology characterized by alterations in tendon
microstructure, cellularity and collagen composition. Challenged by the possibility of …
microstructure, cellularity and collagen composition. Challenged by the possibility of …
[HTML][HTML] Tissue engineering of skeletal muscle, tendons and nerves: A review of manufacturing strategies to meet structural and functional requirements
N Pien, H Krzyslak, SS Kallaje, J Van Meerssche… - Applied Materials …, 2023 - Elsevier
Additive manufacturing technologies have become at the forefront in tissue engineering,
enabling the fabrication of complex tissues with intricate geometries that were not feasible …
enabling the fabrication of complex tissues with intricate geometries that were not feasible …
The bumpy road to stem cell therapies: Rational design of surface topographies to dictate stem cell mechanotransduction and fate
J Carthew, JBJ Taylor, MR Garcia-Cruz… - … Applied Materials & …, 2022 - ACS Publications
Cells sense and respond to a variety of physical cues from their surrounding
microenvironment, and these are interpreted through mechanotransductive processes to …
microenvironment, and these are interpreted through mechanotransductive processes to …
Microfluidically aligned collagen to maintain the phenotype of tenocytes in vitro
F Giacomini, D Baião Barata, H Suk Rho… - Advanced …, 2024 - Wiley Online Library
Tendon is a highly organized tissue that transmits forces between muscle and bone. The
architecture of the extracellular matrix of tendon, predominantly from collagen type I, is …
architecture of the extracellular matrix of tendon, predominantly from collagen type I, is …
[HTML][HTML] Replication of natural surface topographies to generate advanced cell culture substrates
Surface topographies of cell culture substrates can be used to generate in vitro cell culture
environments similar to the in vivo cell niches. In vivo, the physical properties of the …
environments similar to the in vivo cell niches. In vivo, the physical properties of the …
[HTML][HTML] An off-the-shelf decellularized and sterilized human bone-ACL-bone allograft for anterior cruciate ligament reconstruction
JA Uquillas, J Spierings, A van der Lande… - journal of the …, 2022 - Elsevier
Approximately 1% of active individuals participating in sports rupture their anterior cruciate
ligaments (ACL) every year, which is currently reconstructed using tendon autografts. Upon …
ligaments (ACL) every year, which is currently reconstructed using tendon autografts. Upon …
[HTML][HTML] Self-agglomerated collagen patterns govern cell behaviour
Reciprocity between cells and their surrounding extracellular matrix is one of the main
drivers for cellular function and, in turn, matrix maintenance and remodelling. Unravelling …
drivers for cellular function and, in turn, matrix maintenance and remodelling. Unravelling …
[HTML][HTML] Cells dynamically adapt to surface geometry by Remodeling their focal adhesions and actin cytoskeleton
A Dede Eren, AWA Lucassen, U Tuvshindorj… - Frontiers in Cell and …, 2022 - frontiersin.org
Cells probe their environment and adapt their shape accordingly via the organization of
focal adhesions and the actin cytoskeleton. In an earlier publication, we described the …
focal adhesions and the actin cytoskeleton. In an earlier publication, we described the …
Multiscale characterization of pathological bone tissue
ED Eren, WH Nijhuis, F van der Weel… - Microscopy …, 2022 - Wiley Online Library
Bone is a complex natural material with a complex hierarchical multiscale organization,
crucial to perform its functions. Ultrastructural analysis of bone is crucial for our …
crucial to perform its functions. Ultrastructural analysis of bone is crucial for our …
[HTML][HTML] Nonwoven-based gelatin/polycaprolactone membrane loaded with ERK inhibitor U0126 for treatment of tendon defects
Y Hou, B Zhou, M Ni, M Wang, L Ding, Y Li… - Stem Cell Research & …, 2022 - Springer
Background Tendon is a major component of musculoskeletal system connecting the
muscles to the bone. Tendon injuries are very common orthopedics problems leading to …
muscles to the bone. Tendon injuries are very common orthopedics problems leading to …