Targeting the multifunctional HBV core protein as a potential cure for chronic hepatitis B
The core (capsid) protein of hepatitis B virus (HBV) is the building block of nucleocapsids
where viral DNA reverse transcriptional replication takes place and mediates virus-host cell …
where viral DNA reverse transcriptional replication takes place and mediates virus-host cell …
Current progress in the development of hepatitis B virus capsid assembly modulators: chemical structure, mode-of-action and efficacy
H Kim, C Ko, JY Lee, M Kim - Molecules, 2021 - mdpi.com
Hepatitis B virus (HBV) is a major causative agent of human hepatitis. Its viral genome
comprises partially double-stranded DNA, which is complexed with viral polymerase within …
comprises partially double-stranded DNA, which is complexed with viral polymerase within …
Novel potent capsid assembly modulators regulate multiple steps of the hepatitis B virus life cycle
T Lahlali, JM Berke, K Vergauwen, A Foca… - Antimicrobial agents …, 2018 - Am Soc Microbiol
The assembly of hepatitis B virus (HBV) core protein (HBc) into capsids represents a critical
step of viral replication. HBc has multiple functions during the HBV life cycle, which makes it …
step of viral replication. HBc has multiple functions during the HBV life cycle, which makes it …
Novel non-HAP class A HBV capsid assembly modulators have distinct in vitro and in vivo profiles
H Vanrusselt, DB Kum, V Taverniti, C Liu… - Journal of …, 2023 - Am Soc Microbiol
Capsid assembly modulators (CAMs) are a novel class of therapeutic small molecules with
the potential to address the continued global challenge posed by chronic hepatitis B (CHB) …
the potential to address the continued global challenge posed by chronic hepatitis B (CHB) …
Novel Hepatitis B Virus Capsid Assembly Modulator Induces Potent Antiviral Responses In Vitro and in Humanized Mice
F Amblard, S Boucle, L Bassit, B Cox… - Antimicrobial agents …, 2020 - Am Soc Microbiol
Hepatitis B virus (HBV) affects an estimated 250 million chronic carriers worldwide. Though
several vaccines exist, they are ineffective for those already infected. HBV persists due to the …
several vaccines exist, they are ineffective for those already infected. HBV persists due to the …
Class A capsid assembly modulator apoptotic elimination of hepatocytes with high HBV core antigen level in vivo is dependent on de novo core protein translation
JM Berke, Y Tan, S Sauviller, D Wu, K Zhang… - Journal of …, 2024 - Am Soc Microbiol
Capsid assembly is critical in the hepatitis B virus (HBV) life cycle, mediated by the viral core
protein. Capsid assembly is the target for new anti-viral therapeutics known as capsid …
protein. Capsid assembly is the target for new anti-viral therapeutics known as capsid …
SUMO modification of hepatitis B virus core mediates nuclear entry, promyelocytic leukemia nuclear body association, and efficient formation of covalently closed …
S Hofmann, V Plank, P Groitl, N Skvorc… - Microbiology …, 2023 - Am Soc Microbiol
Persistence of hepatitis B virus (HBV) infection is due to a nuclear covalently closed circular
DNA (cccDNA), generated from the virion-borne relaxed circular DNA (rcDNA) genome in a …
DNA (cccDNA), generated from the virion-borne relaxed circular DNA (rcDNA) genome in a …
[HTML][HTML] Novel non-heteroarylpyrimidine (HAP) capsid assembly modifiers have a different mode of action from HAPs in vitro
A Corcuera, K Stolle, S Hillmer, S Seitz, JY Lee… - Antiviral research, 2018 - Elsevier
One of the most promising viral targets in current hepatitis B virus (HBV) drug development
is the core protein due to its multiple roles in the viral life cycle. Here we investigated the …
is the core protein due to its multiple roles in the viral life cycle. Here we investigated the …
Discovery of novel hepatitis B virus nucleocapsid assembly inhibitors
Hepatitis B virus (HBV) core protein is a small protein with 183 amino acid residues and
assembles the pregenomic (pg) RNA and viral DNA polymerase to form nucleocapsids …
assembles the pregenomic (pg) RNA and viral DNA polymerase to form nucleocapsids …
3D-QSAR, molecular docking and molecular dynamics simulations analyses of a series of heteroaryldihydropyrimidine derivatives as hepatitis B virus capsid …
L Chen, WG Liu, F Xiong, C Ma, C Sun… - New Journal of …, 2021 - pubs.rsc.org
The HBV capsid protein (CP) plays a vital role in the multiple life cycles of HBV and
represents a novel anti-HBV target. Recently, a novel series of heteroaryldihydropyrimidine …
represents a novel anti-HBV target. Recently, a novel series of heteroaryldihydropyrimidine …