Finding strategies against the development of antibiotic resistance is a major global
challenge for the life sciences community and for public health. The past decades have seen …

Bacterial multidrug efflux pumps have come to prominence in human and veterinary
pathogenesis because they help bacteria protect themselves against the antimicrobials …

The most common prokaryotic signal transduction mechanisms are the one-component
systems in which a single polypeptide contains both a sensory domain and a DNA-binding …

Tuberculosis is today amongst the worldwide health threats. As resistant strains of
Mycobacterium tuberculosis have slowly emerged, treatment failure is too often a fact …

Antibiotic resistance is one of the biggest threats to human health globally. Alarmingly,
multidrug-resistant and extensively drug-resistant Mycobacterium tuberculosis have now …

Tuberculosis (TB) is a slow growing, potentially debilitating disease that has plagued
humanity for centuries and has claimed numerous lives across the globe. Concerted efforts …

Summary The Mycobacterium tuberculosis TetR‐type regulator Rv3574 has been implicated
in pathogenesis as it is induced in vivo, and genome‐wide essentiality studies show it is …

The side effects associated with tuberculosis therapy bring with them the risk of
noncompliance and subsequent drug resistance. Increasing the therapeutic index of …

In Escherichia coli, cytokinesis is orchestrated by FtsZ, which forms a Z‐ring to drive
septation. Spatial and temporal control of Z‐ring formation is achieved by the Min and …

Bacteria transcriptional regulators are classified by their functional and sequence
similarities. Member of the TetR/AcrR family is two-domain proteins including an N-terminal …